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Estrogen Receptor-α in Female Skeletal Muscle is Not Required for Regulation of Muscle Insulin Sensitivity and Mitochondrial Regulation

McClung, Joseph M.; Iñigo, Melissa R.; Amorese, Adam J.; Tarpey, Michael D.; Balestrieri, Nicholas P.; Jones, Keith G.; Patteson, Daniel J.; Torres, Maria.J.; Lin, Chien-Te; Smith, Cody D.; Heden, Timothy D.; McMillin, Shawna L.; Weyrauch, Luke A.; Stanley, Erin C.; Schmidt, Cameron A.; Funai, Katsuhiko; Gowdy, Kymberly M.; Witczak, Carol A.; Neufer, P. Darrell; Spangenburg, Espen E. (2020-04-01)

Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery

Bikman, Benjamin Thomas; Zheng, Donghai; Pories, Walter J.; Chapman, William H. H.; Pender, John R.; Bowden, Rita C.; Reed, Melissa A.; Cortright, Ronald N.; Tapscott, Edward B.; Houmard, Joseph A.; Tanner, Charles J.; Lee, Jihyun; Dohm, G. Lynis (East Carolina University, 2008-12)

Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ...

Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats.

Dolan, Patricia L.; Tapscott, Edward B.; Dorton, Peter J.; Dohm, G. Lynis (East Carolina University, 1993-01-15)

Both insulin and contraction stimulate glucose transport in skeletal muscle. Insulin-stimulated glucose transport is decreased in obese humans and rats. The aims of this study were (1) to determine if contraction-stimulated ...

The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes

Amato, Christina L. (East Carolina University, 2011)

Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ...

The effect of fasting on the activation in vivo of the insulin receptor kinase.

Contreras, Ivan; Dohm, G. Lynis; Abdallah, Silvia; Wells, James A.; Mooney, Nitin; Rovira, Adela; Caro, Jose F. (East Carolina University, 1990-02-01)

Fasting causes insulin resistance in liver and fat, and increases insulin sensitivity in muscle. We studied the response in vitro and in vivo to insulin of the insulin receptor tyrosine kinase in muscle and liver from 72 ...