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    Author
    Durante, William (3)
    Peyton, Kelly J. (3)Tulis, David A. (3)Keswani, Amit N. (2)Liu, Xiao-Ming (2)Wang, Hong (2)Azam, Mohammed A. (1)Ensenat, Diana (1)Kannan, Sankaranarayanan (1)Mendelev, Natalia N. (1)... View MoreSubjectYC-1 (2)Apoptosis (1)Arginase (1)Carotid artery balloon injury (1)Monoxide-generating enzymes (1)Neointima (1)Proliferation (1)Smooth muscle (1)Vascular smooth muscle cell poliferation (1)Zaprinast (1)... View MoreDate Issued2009 (3)Has File(s)Yes (3)

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    Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries 

    Peyton, Kelly J.; Ensenat, Diana; Azam, Mohammed A.; Keswani, Amit N.; Kannan, Sankaranarayanan; Liu, Xiao-Ming; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-04)
    Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This study investigated the impact of arginase on ...
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    YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells 

    Liu, Xiao-Ming; Peyton, Kelly J.; Mendelev, Natalia N.; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-01)
    The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and ...
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    The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects 

    Keswani, Amit N.; Peyton, Kelly J.; Durante, William; Schafer, Andrew I.; Tulis, David A. (East Carolina University, 2009-06)
    Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however, the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing ...

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