Now showing items 1-6 of 6
Linking energy state to redox environment through mitochondrial redox circuits
(East Carolina University, 2016-11-16)
Mitochondria are the primary producers of intracellular H2O2, an oxidant signaling molecule that has gained attention for its role in normal physiological processes and disease etiologies such as skeletal muscle insulin ...
Essential role of proteasomes in maintaining self-renewal in neural progenitor cells
Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent ...
Modulation of experimental autoimmune myocarditis with cytokine-myosin fusion proteins and novel cardiac peptides
Infectious agents that induce cross-reactive myocarditic T cell responses may cause autoimmune inflammation of the heart, dilated cardiomyopathy (DCM), and heart failure. The purpose of this study was to evaluate the ...
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
(East Carolina University, 2016-05-03)
Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ...
Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury
Background:The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability ...
Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration
(East Carolina University, 2016-09-08)
Cardiovascular disease (CVD) is a multi-faceted pathology that remains the number one killer of all Americans and people worldwide. Vascular inflammation, endothelial dysfunction, extracellular matrix imbalance, and arterial ...