Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children
Author
Stuart, Andrew; Jones, Sherri M.
Abstract
Distortion product otoacoustic emissions (DPOAEs) were examined in 15 normal- hearing African-American children between the ages of 6 and 14 years with homozygous sickle cell disease (SCD), who were on a regimen of hydroxyurea (HDU), a drug that reduces inflammatory processes and symptoms of SCD; a matched group of 15 African- American children with homozygous SCD not on HDU; and 15 African-American children with normal hemoglobin. DPOAEs were evoked by 13 primary tone pairs with f2 frequencies ranging from 1000 to 4500 Hz. Increased DPOAE amplitudes, believed to be a precursor of eventual hearing loss, were evident in children with SCD who were not receiving HDU. Those taking HDU had DPOAE amplitudes similar to normal controls. These findings suggest that HDU, in addition to reducing symptoms of SCD, may play a role in inhibiting or preventing cochlear pathology and hearing loss in individuals with SCD. Key Words: distortion product otoacoustic emissions; sickle cell disease; hydroxyurea Abbreviations: ABR = auditory brainstem response; DPOAE = distortion product otoacoustic emission; HDU = hydroxyurea; HbSS = homozygous sickle cell disease; ICAM = intercellular adhesion molecule; M = mean; OAE = otoacoustic emission; p = probability; PECAM = platelet-endothelial cell adhesion molecule SCD = sickle cell disease; SD = standard deviation of the mean; SOAE = spontaneous otoacoustic emission; TEOAE = transient evoked otoacoustic emission; VCAM = vascular cell adhesion molecule.
Date
2006
Citation:
APA:
Stuart, Andrew, & Jones, Sherri M.. (January 2006).
Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children.
Hearing Research,
212(1-2),
83-
2 p. 83-89. Retrieved from
http://hdl.handle.net/10342/1094
MLA:
Stuart, Andrew, and Jones, Sherri M..
"Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children". Hearing Research.
212:1-2. (83-89),
January 2006.
September 21, 2023.
http://hdl.handle.net/10342/1094.
Chicago:
Stuart, Andrew and Jones, Sherri M.,
"Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children," Hearing Research 212, no.
1-2 (January 2006),
http://hdl.handle.net/10342/1094 (accessed
September 21, 2023).
AMA:
Stuart, Andrew, Jones, Sherri M..
Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children. Hearing Research.
January 2006;
212(1-2):
83-89.
http://hdl.handle.net/10342/1094. Accessed
September 21, 2023.
Collections
Publisher
East Carolina University