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Integrative Complexity of Coastal Resources Management: Examining Tradeoffs Between Ecosystem Protection and Resource Use
(East Carolina University, 2018-07-20)
The management dilemma of use versus protection is a complex issue, and like most complex issues, it does not lend itself to a simple or simplistic solution. This dissertation research examined the connection between ...
The Functional Roles of pH-sensing G protein-coupled receptors in Intestinal Inflammation
(East Carolina University, 2018-12-06)
The inflammatory microenvironment in inflammatory bowel disease (IBD) is complex, replete with microbial byproducts, complement, leukocytes, and resulting inflammatory cytokines. Parallel to these microenvironmental factors ...
On a Sea of Sand: A Comparative Analysis of the Challenges to Beached Wreck Site Stability and Management
(East Carolina University, 2017-04-28)
The archaeological remains of ships in the beach zone are part of a complex and dynamic system, being periodically exposed and reburied, they vary between being both visible and frequently forgotten features of the physical ...
Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP
(East Carolina University, 2010)
The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell ...
Reproductive Toxicity of Crude oil-Dispersant Mixture in Caenorhabditis elegans
(East Carolina University, 2016-05-05)
As crude oil remains a vital natural resource for the energy need of the world, environmental crude oil spills continue to be a health risk to human beings and ecological systems. During clean-up efforts, surfactant-like ...
Re-evaluation of coastal cultural heritage resources : case study of North Carolina southeastern coastal region
(East Carolina University, 2016-12-15)
Humans have had a long history of interconnectedness with the sea and ocean due to the use of natural resources available in the coastal areas. These interactions have influenced the natural landscape and played a crucial ...
Decisions Under Duress: Influences on Official Decision Making During Superstorm Sandy
(East Carolina University, 2015-12-08)
During impending storms, emergency managers and politicians are tasked with the difficult decision of whether or not to issue evacuation orders for their area. This study uses Superstorm Sandy as a case study and investigates ...
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
(East Carolina University, 2016-05-03)
Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ...
Issues of Criticism and Authorship in Arthur Miller's All My Sons : A Bakhtinian Reading
(East Carolina University, 2011)
All my Sons may not be Miller's most known work today, but it is the play that brought him recognition as a playwright. Since its first production, in 1947, critics have assessed the play's content and characters through ...
The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response
(East Carolina University, 2010)
Poxviruses are large double-stranded DNA viruses with a broad host range and worldwide distribution. The most infamous poxvirus is Variola virus, the causative agent of smallpox, which caused over 500 million deaths in ...