Browsing Dissertations by Title
Now showing items 965-984 of 1044
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THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
(East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ... -
The Tree to Success: Using Decision Tree Analysis to Predict Employee Performance and Health
(East Carolina University, 2015-12-10)The purpose of the current study was to evaluate the relative advantages and disadvantages of a novel statistical technique within the context of personnel decision-making. Specifically, the use of decision tree analysis ... -
The Tumor Suppressive Effects of T Cell Death-Associated Gene 8 in Blood Cancers
(East Carolina University, 2017-03-16)In the early twentieth century Otto Warburg recognized a metabolic phenomenon that transpired in cancer cells, currently known as the Warburg Effect. Warburg discovered cancer cells favor glycolysis rather than oxidative ... -
THE π-H ELIX IN FMN-DEPENDENT REDUCTASES PROMOTES OLIGOMERIC CHANGES TO COORDINATE THE MECHANISMS OF THE ALKANESULFONATE MONOOXYGENASE SYSTEMS
(East Carolina University, 2023-08-08)Bacteria two-component flavin-dependent systems are upregulated for sulfur acquisition under sulfur limiting conditions. Two-component flavin-dependent systems are comprised of a reductase (SsuE/MsuE) that catalyzes the ... -
THEOLOGICAL DISCUSSION AND INSTITUTIONAL CHANGE AT A CHURCH-RELATED INSTITUTION
(East Carolina University, 2012)This study explores the relationship between theological discussion and organizational change within a church-related institution. The qualitative case study examines the dialogue on a campus that received a Lilly Endowment ... -
THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT
(East Carolina University, 2019-05-07)Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the ... -
The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ... -
THERE’S TWO SIDES TO EVERY STORY: EXPANDING THE NOMOLOGICAL NETWORK OF BURNOUT THROUGH THE PERSON-ENVIRONMENT INTERACTION
(East Carolina University, 8/5/2020)Burnout is a psychological syndrome consisting of emotional exhaustion, cynicism, and reduced personal accomplishment. It is associated with a depletion of intrinsic resources that results from prolonged exposure to ... -
Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
(East Carolina University, 2011)With the over prescription and use of antibiotic drugs the evolution of drug resistant bacteria strains has become a world wide health crisis. In response to this crisis, the search for new drugs to kill bacteria via a ... -
They're Speaking Gender Identity, Agency, and Belonging in an International Middle School
(East Carolina University, 2023-04-17)The purpose of the study was to better understand how international school middle school teachers can help cultivate a student's sense of belonging by creating a space for students to explore factors shaping their gender ... -
THREAT ASSESSMENT AND MANAGEMENT: PROTOCOL AND BUDGETARY NEEDS FOR TOOLS AND MEMBER TRAINING IN HIGHER EDUCATION
(East Carolina University, 2021-04-20)The primary goal of threat assessment is to prevent individuals who are on a pathway to violence. Threat assessment entails a three-step process beginning with identifying a concern, assessing the risk and managing the ... -
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
(East Carolina University, 2016-05-03)Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ... -
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ... -
TLR-4 agonism induces CD25+ MHCIIhigh dendritic cells in association with tolerogenic antigen recognition
(East Carolina University, 2022-12-06)Autoimmune disease is a result of the breakdown in immunological self-tolerance leading to destruction of self-tissues mediated by the aberrant immune attack. In Multiple Sclerosis (MS), CD4+ T cells mediate destruction ... -
Toward a balanced demographic: A case study of parents's preference for rural charter schools
(East Carolina University, 2018-04-09)Against a background of failure on the part of the focus of this case study to adhere to its founding charter in terms of enrollment, the purpose of this study was to explore how and why rural parents choose charter schools ... -
Toward increasing leadership capacity in nurses: an exploration of the state and future perspectives of leadership education in pre-licensure baccalaureate nursing programs.
(East Carolina University, 2015)The purpose of this study was to explore and describe the state and future perspectives of leadership education in pre-licensure baccalaureate nursing programs. Study objectives were to describe nurse educator and practice ... -
Training Effects on Recovering Parents' Self-Efficacy to Identify Problems, Solutions and Resources to Prevent Internet Addiction in Youth
(East Carolina University, 2017-12-06)This study examined the effects of a 2-hour training on the self-efficacy of parents in recovery from substance use disorder to intercede in their children's Internet technology use in order to prevent future problems with ... -
Transcriptional regulation of 'pqsR', a gene that encodes a regulator of quinolone signal synthesis and virulence in 'Pseudomonas aeruginosa'
(East Carolina University, 2015)The gram-negative bacterium 'Pseudomonas aeruginosa' is an opportunistic pathogen that frequently causes nosocomial infections and serious chronic lung infections in cystic fibrosis patients. During infection 'P. aeruginosa' ... -
TRANSFORMING FAMILY ENGAGEMENT BY DEVELOPING THE CAPACITY OF SCHOOL LEADERS
(East Carolina University, 2021-04-27)This qualitative study was guided by the Dual-Capacity Building Framework for Family-School Partnerships (Mapp & Kuttner, 2013) to explore how elementary principals led family engagement; provided insights into what ...