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Effects of Aerobic Capacity Phenotype on Adaptive Responses to Ischemic Stress
(East Carolina University, 2009)
Ischemic disease leads to increased tissue stress by decreasing supply of nutrients adequate to meet energy demands. To maintain functionality, compensatory mechanisms for diminished vascular supply are induced by numerous ...
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)
Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...