Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection

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Author
Hamden, Khalief E.; Ford, Patrick W.; Whitman, Audy G.; Dyson, Ossie F.; Cheng, Shi-Yuan; McCubrey, James A.; Akula, Shaw M.
Abstract
Recombinant green fluorescent protein encoding Kaposi’s sarcoma-associated herpesvirus (rKSHV.152) infection of -estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ B-Raf[FF]:ER (expressing a weaker form of B-Raf) could be enhanced to levels comparable to that of HFF/ B-Raf[DD]:ER cells by pretreating cells with soluble vascular endothelial growth factor (VEGF). Conversely, VEGF expression and infection efficiency typically observed in -estradiol stimulated HFF/ B-Raf[DD]:ER cells could be lowered significantly by treating with VEGF small interfering RNA. In addition, we observed enhancement of the KSHV infection in HFF cells transfected with human VEGF121. These results confirm the ability of Raf-induced VEGF to augment KSHV infection of cells. Originally published Journal of Virology Dec. 2004, Vol. 78 No. 23
URI
http://hdl.handle.net/10342/3016
Subject
 Kaposi’s sarcoma-associated herpes virus; Human herpes virus 8; Vascular endothelial growth factor 
Date
2004-12
Citation:
APA:
Hamden, Khalief E., & Ford, Patrick W., & Whitman, Audy G., & Dyson, Ossie F., & Cheng, Shi-Yuan, & McCubrey, James A., & Akula, Shaw M.. (December 2004). Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection. , (. Retrieved from http://hdl.handle.net/10342/3016

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MLA:
Hamden, Khalief E., and Ford, Patrick W., and Whitman, Audy G., and Dyson, Ossie F., and Cheng, Shi-Yuan, and McCubrey, James A., and Akula, Shaw M.. "Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection". . . (.), December 2004. February 23, 2020. http://hdl.handle.net/10342/3016.
Chicago:
Hamden, Khalief E. and Ford, Patrick W. and Whitman, Audy G. and Dyson, Ossie F. and Cheng, Shi-Yuan and McCubrey, James A. and Akula, Shaw M., "Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection,"  , no. (December 2004), http://hdl.handle.net/10342/3016 (accessed February 23, 2020).
AMA:
Hamden, Khalief E., Ford, Patrick W., Whitman, Audy G., Dyson, Ossie F., Cheng, Shi-Yuan, McCubrey, James A., Akula, Shaw M.. Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection. . December 2004; () . http://hdl.handle.net/10342/3016. Accessed February 23, 2020.
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Publisher
East Carolina University