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    Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice

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    Author
    Jones, Timothy A.; Jones, Sherri M.; Hoffman, L. F.
    Abstract
    Vestibular primary afferents in the normal mammal are spontaneously active. The consensus hypothesis states that such discharge patterns are independent of stimulation and depend instead on excitation by vestibular hair cells due to background release of synaptic neurotransmitter. In the case of otoconial sensory receptors, it is difficult to test the independence of resting discharge from natural tonic stimulation by gravity. We examined this question by studying discharge patterns of single vestibular primary afferent neurons in the absence of gravity stimulation using two mutant strains of mice that lack otoconia (OTO-; head tilt, het-Nox3, and tilted, tlt-Otop1). Our findings demonstrated that macular primary afferent neurons exhibit robust resting discharge activity in OTO- mice. Spike interval coefficient of variation (CV=SD/mean spike interval) values reflected both regular and irregular discharge patterns in OTO- mice, and the range of values for rate-normalized CV was similar to mice and other mammals with intact otoconia although there were proportionately fewer irregular fibers. Mean discharge rates were slightly higher in otoconia-deficient strains even after accounting for proportionately fewer irregular fibers [OTO-=75.4±31.1(113) vs OTO+=68.1±28.5(143) in sp/s]. These results confirm the hypothesis that resting activity in macular primary afferents occurs in the absence of ambient stimulation. The robust discharge rates are interesting in that they may reflect the presence of a functionally ‘up-regulated’ tonic excitatory process in the absence of natural sensory stimulation. Originally published in Journal of the Association for Research in Otolaryngology Vol. 9, No. 4 2008.
    URI
    http://hdl.handle.net/10342/3023
    Subject
     Sensory deprivation; Spontaneous activity; Resting activity; Vestibular ganglion cells; Primary afferents of the macula; Vestibular macula; Gravity receptors; Vestibular spontaneous activity; Discharge patterns 
    Date
    2008-12
    Citation:
    APA:
    Jones, Timothy A., & Jones, Sherri M., & Hoffman, L. F.. (December 2008). Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice. , (. Retrieved from http://hdl.handle.net/10342/3023

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    MLA:
    Jones, Timothy A., and Jones, Sherri M., and Hoffman, L. F.. "Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice". . . (.), December 2008. March 07, 2021. http://hdl.handle.net/10342/3023.
    Chicago:
    Jones, Timothy A. and Jones, Sherri M. and Hoffman, L. F., "Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice,"  , no. (December 2008), http://hdl.handle.net/10342/3023 (accessed March 07, 2021).
    AMA:
    Jones, Timothy A., Jones, Sherri M., Hoffman, L. F.. Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice. . December 2008; () . http://hdl.handle.net/10342/3023. Accessed March 07, 2021.
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    • Communication Sciences and Disorders
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    East Carolina University

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