• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Division of Health Sciences
    • Brody School of Medicine
    • Emergency Med
    • View Item
    •   ScholarShip Home
    • Division of Health Sciences
    • Brody School of Medicine
    • Emergency Med
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies.

    Thumbnail
    View/ Open
    Hypoth for induct and prop.pdf (1.561Mb)

    Show full item record
    
    Author
    Meggs, William J.
    Abstract
    The reactive airways dysfunction syndrome (RADS), the reactive upper airways dysfunction syndrome (RUDS), the sick building syndrome (SBS), and the multiple chemical sensitivity syndrome (MCS) are overlapping disorders in which there is an intolerance to environmental chemicals. The onset of these illnesses is often associated with an initial acute chemical exposure. To understand the pathophysiology of these conditions, a study of the nasal pathology of individuals experiencing these syndromes was undertaken. Preliminary data indicate that the nasal pathology of these disorders is characterized by defects in tight junctions between cells, desquamation of the respiratory epithelium, glandular hyperplasia, lymphocytic infiltrates, and peripheral nerve fiber proliferation. These findings suggest a model for a relationship between the chronic inflammation seen in these conditions and an individual's sensitivity to chemicals. A positive feedback loop is set up: the inflammatory response to low levels of chemical irritants is enhanced due to the observed changes in the epithelium, and the epithelial changes are propagated by the inflammatory response to the chemicals. This model, combined with the concept of neurogenic switching, has the potential to explain many aspects of RADS, RUDS, SBS, and MCS in a unified way. Originally published Environ Health Perspect 105(Suppl 2):473-478 (1997)
    URI
    http://hdl.handle.net/10342/3054
    Subject
     Rhinitis; Asthma; Sick building syndrome; Multiple chemical sensitivity syndrome; Reactive airways dysfunction syndrome; Reactive upper airways dysfunction syndrome; Neurogenic inflammation; Neurogenic switching 
    Date
    1997-03
    Citation:
    APA:
    Meggs, William J.. (March 1997). Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies.. Environmental Health Perspectives, (105:Suppl 2), p.473-478. Retrieved from http://hdl.handle.net/10342/3054

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Meggs, William J.. "Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies.". Environmental Health Perspectives. 105:Suppl 2. (473-478.), March 1997. March 04, 2021. http://hdl.handle.net/10342/3054.
    Chicago:
    Meggs, William J., "Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies.," Environmental Health Perspectives 105, no. Suppl 2 (March 1997), http://hdl.handle.net/10342/3054 (accessed March 04, 2021).
    AMA:
    Meggs, William J.. Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies.. Environmental Health Perspectives. March 1997; 105(Suppl 2) 473-478. http://hdl.handle.net/10342/3054. Accessed March 04, 2021.
    Collections
    • Emergency Med
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback