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    Effects of Cage-Change Frequency and Bedding Volume on Mice and Their Microenvironment

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    Author
    Rosenbaum, Matthew D.; VandeWoude, Susan; Johnson, Thomas E.
    Abstract
    The frequency at which mouse cages are changed has important implications for the animals, animal care personnel, and facility managers. The objective of this study was to determine how bedding volume and the interval between changes affect microenvironmental conditions, health, and behavior of mice housed in individually ventilated cages (IVC). A total of 15 cages (n = 5 cages per bedding volume) housing ICR female mice (n = 5 animals per cage) were monitored for 17 d. Parameters monitored included clinical evaluation of each animal, appearance of the cage, fecal corticosterone levels, bedding weight, and mouse mass. Atmospheric analysis was performed daily to determine intracage ammonia cage humidity and temperature on a daily basis. Mice were videotaped for 10 min on days 1, 8, and 15, and videos were analyzed for abnormal behaviors. On day 17, 1 mouse from each cage was euthanized, and bronchoalveolar lavage was performed. Statistical differences in parameters were most often noted between low- and high-volume bedding groups. Correlation between visual appearance and actual intracage environmental conditions and mouse health and behavior at specific time points indicated cages that appear dirty to most observers did not have measurably adverse effects on the animals for any of the many parameters evaluated in this study. This study demonstrated that a 2-wk interval between cage changes for ICR female mice housed in IVC caging (with approximately 90 air changes per hour) and aspen chip bedding did not significantly affect measures of animal well-being in this study. This lack of effect occurred despite the appearance of excessive soiling by the 2-wk time point. Originally published Journal of the American Association for Laboratory Animal Science, Vol. 48, No. 6, Nov. 2009
    URI
    http://hdl.handle.net/10342/3083
    Subject
     Mouse health; Bedding volume; Microenvironmental conditions 
    Date
    2009-11
    Citation:
    APA:
    Rosenbaum, Matthew D., & VandeWoude, Susan, & Johnson, Thomas E.. (November 2009). Effects of Cage-Change Frequency and Bedding Volume on Mice and Their Microenvironment. Journal of the American Association for Laboratory Animal Science, (48:6), p.763-773. Retrieved from http://hdl.handle.net/10342/3083

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Rosenbaum, Matthew D., and VandeWoude, Susan, and Johnson, Thomas E.. "Effects of Cage-Change Frequency and Bedding Volume on Mice and Their Microenvironment". Journal of the American Association for Laboratory Animal Science. 48:6. (763-773.), November 2009. August 15, 2022. http://hdl.handle.net/10342/3083.
    Chicago:
    Rosenbaum, Matthew D. and VandeWoude, Susan and Johnson, Thomas E., "Effects of Cage-Change Frequency and Bedding Volume on Mice and Their Microenvironment," Journal of the American Association for Laboratory Animal Science 48, no. 6 (November 2009), http://hdl.handle.net/10342/3083 (accessed August 15, 2022).
    AMA:
    Rosenbaum, Matthew D., VandeWoude, Susan, Johnson, Thomas E.. Effects of Cage-Change Frequency and Bedding Volume on Mice and Their Microenvironment. Journal of the American Association for Laboratory Animal Science. November 2009; 48(6) 763-773. http://hdl.handle.net/10342/3083. Accessed August 15, 2022.
    Collections
    • Comparative Medicine
    Publisher
    East Carolina University

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