• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Academic Affairs
    • Thomas Harriot College of Arts and Sciences
    • Biology
    • View Item
    •   ScholarShip Home
    • Academic Affairs
    • Thomas Harriot College of Arts and Sciences
    • Biology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Cadherins in maternal-foetal interactions: red queen with a green beard?

    Thumbnail
    View/ Open
    Cadherins in maternal foetal interactions.pdf (140.3Kb)

    Show full item record
    
    Author
    Summers, Kyle; Crespi, Bernard
    Abstract
    Cadherins are homophilic cell surface adhesion proteins, some of which mediate interactions between maternal and foetal tissues during mammalian pregnancy. David Haig suggested that these proteins may exhibit ‘green-beard gene’ effects, whereby the nature of binding between identical alleles in mother and foetus leads to differential levels of resource transfer. The selfish effects of such self-recognizing alleles should, however, be suppressed over evolutionary time by unlinked genes, which is expected to lead to antagonistic coevolution between placentally expressed cadherins and unlinked modifiers. Such molecular coevolution should leave a signature of positive selection, with high ratios of non-synonymous to synonymous amino acid substitution.We present evidence that three placentally expressed cadherin genes, E-cadherin, P-cadherin and VE-cadherin, have been subject to positive selection. By contrast, a ‘control’ cadherin that is not expressed in the placenta, H-cadherin, showed no evidence of selection. These results provide support for the hypothesis that the cadherin genes involved in maternal–foetal interactions have been subject to green-beard-effect mutations over the course of evolutionary history, leading to antagonistic coevolution with suppressing elements from the parliament of genes. Originally published Proc Biol Sci, Vol. 272, No. 1563, March 2005
    URI
    http://hdl.handle.net/10342/3088
    Subject
     Cadherin; Selection; Placenta; Green-beard 
    Date
    2005-03-22
    Citation:
    APA:
    Summers, Kyle, & Crespi, Bernard. (March 2005). Cadherins in maternal-foetal interactions: red queen with a green beard?. Proceedings of the Royal Society Biological Sciences, (272:1563), p.643-649. Retrieved from http://hdl.handle.net/10342/3088

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Summers, Kyle, and Crespi, Bernard. "Cadherins in maternal-foetal interactions: red queen with a green beard?". Proceedings of the Royal Society Biological Sciences. 272:1563. (643-649.), March 2005. March 08, 2021. http://hdl.handle.net/10342/3088.
    Chicago:
    Summers, Kyle and Crespi, Bernard, "Cadherins in maternal-foetal interactions: red queen with a green beard?," Proceedings of the Royal Society Biological Sciences 272, no. 1563 (March 2005), http://hdl.handle.net/10342/3088 (accessed March 08, 2021).
    AMA:
    Summers, Kyle, Crespi, Bernard. Cadherins in maternal-foetal interactions: red queen with a green beard?. Proceedings of the Royal Society Biological Sciences. March 2005; 272(1563) 643-649. http://hdl.handle.net/10342/3088. Accessed March 08, 2021.
    Collections
    • Biology
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback