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  • Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women 

    Hittel, Dustin S.; Berggren, Jason R.; Shearer, Jane; Boyle, Kristen E.; Houmard, Joseph A. (East Carolina University, 2009-01)
    OBJECTIVE- Obesity is associated with endocrine abnormalities that predict the progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been shown to secrete proteins that could be used as biomarkers, ...
  • Metabolic Inflexibility in Skeletal Muscle With Obesity 

    Boyle, Kristen E. (East Carolina University, 2009)
    The skeletal muscle of obese individuals has a reduced capacity to oxidize lipids. The hypothesis to be tested in this dissertation is that the ability to regulate lipid oxidation in response to lipid exposure is impaired ...