Now showing items 1-20 of 89

  • Transcriptional regulation of muscle fatty acid-binding protein. 

    Carey, Julie O.; Neufer, P. Darrell; Farrar, Roger P.; Veerkamp, Jacques H.; Dohm, G. Lynis (East Carolina University, 1994-03-15)
    Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the expression of H-FABP correlates ...
  • The impact of a repeated bout of eccentric exercise on muscular strength, muscle soreness and creatine kinase. 

    Smith, L. L.; Fulmer, M. G.; Holbert, Donald; McCammon, Michael R.; Houmard, Joseph A.; Frazer, D. D.; Nsien, E.; Israel, R. Gay (East Carolina University, 1994-12)
    The purpose of this study was to determine if there were any beneficial or detrimental effects regarding delayed onset muscle soreness (DOMS), serum creatine kinase (CK), and maximum concentric strength at 80% of 1-RMconc, ...
  • Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans 

    Hortobágyi, Tibor; Dempsey, G. Lynis; Fraser, D. D.; Zheng, D.; Hamilton, G.; Lambert, J.; Dohm, G. Lynis (East Carolina University, 2000-01)
    1. Changes in muscle strength, vastus lateralis fibre characteristics and myosin heavychain (MyoHC) gene expression were examined in 48 men and women following 3 weeks of knee immobilization and after 12 weeks of retraining ...
  • Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium 

    Benjamin, Ramsis K.; Hochberg, Fred H.; Fox, Elizabeth; Bungay, Peter M.; Elmquist, William F.; Stewart, Clinton F.; Gallo, James M.; Collins, Jerry M.; Pelletier, Robert P.; de Groot, John F.; Hickner, Robert C.; Cavus, Idil; Grossman, Stuart A.; Colvin, O. Michael (East Carolina University, 2004-01)
    In individuals with brain tumors, pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid, which unfortunately do not necessarily ...
  • Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle 

    Thomson, David M.; Gordon, Scott Edward (East Carolina University, 2006-07-01)
    Impaired overload-induced protein synthesis and growth in aged fast-twitch skeletal muscle may result from diminished responsiveness of signalling intermediates controlling protein translation. Yet, potential age-related ...
  • Relative fat oxidation is higher in children than adults 

    Kostyak, John C.; Kris-Etherton, Penny; Bagshaw, Deborah; DeLany, James P.; Farrell, Peter A. (East Carolina University, 2007-08-16)
    Background: Prepubescent children may oxidize fatty acids more readily than adults. Therefore, dietary fat needs would be higher for children compared with adults. The dietary fat recommendations are higher for children 4 ...
  • Muscles do more positive than negative work in human locomotion 

    DeVita, Paul, 1955-; Helseth, Joseph; Hortobágyi, Tibor (East Carolina University, 2007-10)
    Muscle work during level walking and ascent and descent ramp and stairway walking was assessed in order to explore the proposition that muscles perform more positive than negative work during these locomotion tasks. Thirty ...
  • No difference in the skeletal muscle angiogenic response 

    Gavin, Timothy Patrick; Ruster, Rebecca S.; Carrithers, John A.; Zwetsloot, Kevin A.; Kraus, Raymond M.; Evans, Christopher A.; Knapp, Deborah J.; Drew, James L.; McCartney, Jennifer S.; Garry, Joseph P.; Hickner, Robert C. (East Carolina University, 2007-11)
    Ischaemia-induced skeletalmuscle angiogenesis is impaired in aged compared with young mice. In humans, vascular endothelial growth factor (VEGF) mRNA and protein following an acute exercise bout are lower in aged compared ...
  • Dietary carbohydrate intake and high sensitivity C reactive protein in at-risk women and men 

    Huffman, Kim M.; Orenduff, Melissa C.; Samsa, Gregory P.; Houmard, Joseph A.; Kraus, William E.; Bales, Connie W. (East Carolina University, 2007-11)
    Background— The quality and quantity of dietary carbohydrate intake, measured as dietary glycemic load (GL), is associated with a number of cardiovascular disease (CVD) risk factors and, in healthy young women, is related ...
  • Exercise Training Amount and Intensity Effects on Metabolic Syndrome (From Studies of a Targeted Risk Reduction Intervention through Defined Exercise) 

    Johnson, Johanna L.; Slentz, Cris A.; Houmard, Joseph A.; Samsa, Gregory P.; Duscha, Brian D.; Aiken, Lori B.; McCartney, Jennifer S.; Tanner, Charles J.; Kraus, William E. (East Carolina University, 2007-12-15)
    Although exercise improves individual risk factors of the metabolic syndrome (MS), there is little research on the effect of exercise on MS as a whole. The objective of this study was to determine how much exercise is ...
  • More Than Just Letting Them Play: Parental Influence on Women's Lifetime Sport Involvement 

    Dixon, Marlene A.; Warner, Stacy; Bruening, Jennifer (East Carolina University, 2008)
    This qualitative study uses expectancy-value and life course theories (Giele & Elder, 1998) to examine both the proximal and distal impact of early family socialization on enduring female participation in sport. Seventeen ...
  • How do low horizontal forces produce disproportionately high torques in human locomotion? 

    Helseth, Joseph; Hortobágyi, Tibor; DeVita, Paul, 1955- (East Carolina University, 2008)
    Although horizontal ground forces are only ~15% of vertical forces, they account for 47% and 33% of the metabolic cost in walking and running. To explain these disproportionately high metabolic costs we hypothesized that ...
  • Intramuscular lipid oxidation and obesity 

    Houmard, Joseph A. (East Carolina University, 2008-04)
    There is an accumulating amount of evidence indicating that lipid oxidation is depressed in the skeletal muscle of obese individuals. Decrements in fatty acid oxidation (FAO) have been reported with obesity in models ranging ...
  • Relationships between Adipose Tissue and Cytokine Responses to a Randomized Controlled Exercise Training Intervention 

    Huffman, Kim M.; Slentz, Cris A.; Bales, Connie W.; Houmard, Joseph A.; Kraus, William E. (East Carolina University, 2008-04)
    Adipose-derived cytokines play a prominent role in mediating the metabolic consequences of obesity and excess body fat. Given this, we hypothesized that alterations in adipose tissue stores incurred with exercise training ...
  • Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle 

    Wooldridge, Anne A.; Fortner, Christopher N.; Lontay, Beata; Akimoto, Takayuki; Neppl, Ronald L.; Facemire, Carie; Datto, Michael B.; Kwon, Ashley; McCook, Everett; Li, Ping; Wang, Shiliang; Thresher, Randy J.; Miller, Sara E.; Perriard, Jean-Claude; Gavin, Timothy Patrick; Hickner, Robert C.; Coffman, Thomas M.; Somlyo, Avril V.; Yan, Zhen; Haystead, Timothy A. J. (East Carolina University, 2008-04-25)
    In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. ...
  • Impact of Hormone Replacement Therapy on Exercise Training-Induced Improvements in Insulin Action in Sedentary Overweight Adults 

    Huffman, Kim M.; Slentz, Cris A.; Johnson, Johanna L.; Samsa, Gregory P.; Duscha, Brian D.; Tanner, Charles J.; Annex, Brian H.; Houmard, Joseph A.; Kraus, William E. (East Carolina University, 2008-07)
    Exercise training (ET) and hormone replacement therapy (HRT) are both recognized influences on insulin action, but the influence of HRT on responses to ET has not been examined. In order to determine if HRT use provided ...
  • Physical activity across the curriculum: year one process evaluation results 

    Gibson, Cheryl A.; Smith, Bryan K.; DuBose, Katrina D.; Greene, J. Leon; Bailey, Bruce W.; Williams, Shannon L.; Ryan, Joseph J.; Schmelzle, Kristin H.; Washburn, Richard A.; Sullivan, Debra K.; Mayo, Matthew S.; Donnelly, Joseph E. (East Carolina University, 2008-07-07)
    Background: Physical Activity Across the Curriculum (PAAC) is a 3-year elementary school-based intervention to determine if increased amounts of moderate intensity physical activity performed in the classroom will diminish ...
  • Does AMP-Activated Protein Kinase Negatively Mediate Aged Fast-Twitch Skeletal Muscle Mass? 

    Gordon, Scott Edward; Lake, Jordan A.; Westerkamp, Christopher M.; Thomson, David M. (East Carolina University, 2008-10)
    The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slowtwitch muscle. Here, we ...
  • Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle 

    Bikman, Benjamin Thomas (East Carolina University, 2008-11)
    Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...
  • Muscle work is biased toward energy generation over dissipation in non-level running 

    DeVita, Paul, 1955-; Janshen, Lars; Rider, Patrick; Solnik, Stanislaw; Hortobágyi, Tibor (East Carolina University, 2008-12-05)
    This study tested the hypothesis that skeletal muscles generate more mechanical energy in gait tasks that raise the center of mass compared to the mechanical energy they dissipate in gait tasks that lower the center of ...