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    Tinigible Body Macrophages in Regulation of Germinal Center Reactions

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    Author
    Smith, John P.; Burton, Gregory F.; Tew, John G.; Szakal, Andras K.
    Abstract
    Tingible body macrophages (TBM), long thought simply as scavengers of apoptotic lymphocytes, are located in the unique microenvironment of germinal centers in close proximity to antigen-retaining follicular dendritic cells (FDC). Observations that TBM endocytose FDCiccosomal (immune-complex coated bodies) antigen suggested that TBM might present this antigen and help regulate the germinal center reaction. To test for antigen presentation, the ovalbumin (OVA)-specific TI hybridoma, 3DO-54.8, which produces IL-2 on receiving effective presentation of OVA, were used as responders to OVA-bearing TBM. Results showed that OVA-bearing TBM failed to induce IL-2 production. Furthermore, addition of TBM to IL- 2-inducing positive controls (B cells) not only failed to augment IL-2 production, but rather TBM significantly (55-90%) reduced B-cell induction of IL-2. We found that TBM were rich in prostaglandin by comparison with other nongerminal center lymph node macrophages and that addition of indomethacin to the cultures reversed the inhibitory effect of TBM. Depletion of TBM from enriched preparations, prior to addition to positive control cultures, also abrogated the inhibitory effect on IL-2 production. These data support the concept that TBM, within the unique microenvironment of germinal centers, may be specialized to downregulate the germinal center reaction. Originally published Developmental Immunology, Vol. 6, No. 3-4, 1998.
    URI
    http://hdl.handle.net/10342/3115
    Subject
     Antigen Presentation; Apoptosis; Iccosomes; Macrophages; Microenvironment; Prostaglandins 
    Date
    1998
    Citation:
    APA:
    Smith, John P., & Burton, Gregory F., & Tew, John G., & Szakal, Andras K.. (January 1998). Tinigible Body Macrophages in Regulation of Germinal Center Reactions. , (. Retrieved from http://hdl.handle.net/10342/3115

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Smith, John P., and Burton, Gregory F., and Tew, John G., and Szakal, Andras K.. "Tinigible Body Macrophages in Regulation of Germinal Center Reactions". . . (.), January 1998. August 17, 2022. http://hdl.handle.net/10342/3115.
    Chicago:
    Smith, John P. and Burton, Gregory F. and Tew, John G. and Szakal, Andras K., "Tinigible Body Macrophages in Regulation of Germinal Center Reactions,"  , no. (January 1998), http://hdl.handle.net/10342/3115 (accessed August 17, 2022).
    AMA:
    Smith, John P., Burton, Gregory F., Tew, John G., Szakal, Andras K.. Tinigible Body Macrophages in Regulation of Germinal Center Reactions. . January 1998; () . http://hdl.handle.net/10342/3115. Accessed August 17, 2022.
    Collections
    • Pharmacology and Toxicology
    Publisher
    East Carolina University

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