• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • ECU Main Campus
    • Thomas Harriot College of Arts and Sciences
    • Biology
    • View Item
    •   ScholarShip Home
    • ECU Main Campus
    • Thomas Harriot College of Arts and Sciences
    • Biology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Evolution of the RNA polymerase II C-terminal domain

    Thumbnail
    View/ Open
    Evolution of RNA polymerase II.pdf (174.8Kb)

    Show full item record
    Author
    Stiller, John W.; Hall, Benjamin D.
    Abstract
    In recent years a great deal of biochemical and genetic research has focused on the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II. This strongly conserved domain of tandemly repeated heptapeptides has been linked functionally to important steps in the initiation and processing of mRNA transcripts in both animals and fungi. Although they are absolutely required for viability in these organisms, C-terminal tandem repeats do not occur in RPB1 sequences from diverse eukaryotic taxa. Here we present phylogenetic analyses of RPB1 sequences showing that canonical CTD heptads are strongly conserved in only a subset of eukaryotic groups, all apparently descended from a single common ancestor. Moreover, eukaryotic groups in which the most complex patterns of ontogenetic development occur are descended from this CTD-containing ancestor. Consistent with the results of genetic and biochemical investigations of CTD function, these analyses suggest that the enhanced control over RNA polymerase II transcription conveyed by acquired CTD protein interactions was an important step in the evolution of intricate patterns of gene expression that are a hallmark of large, developmentally complex eukaryotic organisms. Originally published Proc Natl Acad Sci, Vol. 99, No. 9, Apr 2002
    URI
    http://hdl.handle.net/10342/3122
    Subject
     Development; RPB1; Transcription 
    Date
    2002-04-30
    Citation:
    APA:
    Stiller, John W., & Hall, Benjamin D.. (April 2002). Evolution of the RNA polymerase II C-terminal domain. Proceedings of the National Academy of Science, 99(9), 6091- 6096. Retrieved from http://hdl.handle.net/10342/3122

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Stiller, John W., and Hall, Benjamin D.. "Evolution of the RNA polymerase II C-terminal domain". Proceedings of the National Academy of Science. 99:9. (6091-6096), April 2002. September 23, 2023. http://hdl.handle.net/10342/3122.
    Chicago:
    Stiller, John W. and Hall, Benjamin D., "Evolution of the RNA polymerase II C-terminal domain," Proceedings of the National Academy of Science 99, no. 9 (April 2002), http://hdl.handle.net/10342/3122 (accessed September 23, 2023).
    AMA:
    Stiller, John W., Hall, Benjamin D.. Evolution of the RNA polymerase II C-terminal domain. Proceedings of the National Academy of Science. April 2002; 99(9): 6091-6096. http://hdl.handle.net/10342/3122. Accessed September 23, 2023.
    Collections
    • Biology
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback