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    Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery

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    Author
    Bikman, Benjamin Thomas; Zheng, Donghai; Pories, Walter J.; Chapman, William H. H.; Pender, John R.; Bowden, Rita C.; Reed, Melissa A.; Cortright, Ronald N.; Tapscott, Edward B.; Houmard, Joseph A.; Tanner, Charles J.; Lee, Jihyun; Dohm, G. Lynis
    Abstract
    Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the mechanisms that explain the improvement in insulin sensitivity. Design: We performed a cross-sectional, nonrandomized, controlled study. Setting: This study was conducted jointly between the Departments of Exercise Science and Physiology at East Carolina University in Greenville, North Carolina. Subjects: Subjects were recruited into four groups: 1) lean body mass index (BMI) 25 kg/m2; n 93 ; 2) weight-matched (BMI 25 to 35 kg/m2; n 310); 3) morbidly obese (BMI 35 kg/m2; n 43); and 4) postsurgery patients (BMI 30 kg/m2; n 40). Postsurgery patients were weight stable 1 yr after surgery. Main Outcome Measures: Whole-body insulin sensitivity, muscle glucose transport, and muscle insulin signaling were assessed. Results: Postsurgery subjects had insulin sensitivity index values that were similar to the lean and higher than morbidly obese and weight-matched control subjects. Glucose transport was higher in the postsurgery vs. morbidly obese and weight-matched groups. IRS1-pSer312 in the postsurgery group was lower than morbidly obese and weight-matched groups. Inhibitor B was higher in the postsurgery vs. the morbidly obese and weight-matched controls, indicating reduced inhibitor of B kinase activity. Conclusions: Insulin sensitivity and glucose transport are greater in the postsurgery patients than predicted from the weight-matched group, suggesting that improved insulin sensitivity after bypass is due to something other than, or in addition to, weight loss. Improved insulin sensitivity is related to reduced inhibitor of B kinase activity and enhanced insulin signaling in muscle. Originally published J Clin Endocrinol Metab, Vol. 93, No. 12, Dec 2008
    URI
    http://hdl.handle.net/10342/3220
    Subject
     Diabetes; Insulin sensitivity; Gastric bypass; Obesity 
    Date
    2008-12
    Citation:
    APA:
    Bikman, Benjamin Thomas, & Zheng, Donghai, & Pories, Walter J., & Chapman, William H. H., & Pender, John R., & Bowden, Rita C., & Reed, Melissa A., & Cortright, Ronald N., & Tapscott, Edward B., & Houmard, Joseph A., & Tanner, Charles J., & Lee, Jihyun, & Dohm, G. Lynis. (December 2008). Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery. , (. Retrieved from http://hdl.handle.net/10342/3220

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Bikman, Benjamin Thomas, and Zheng, Donghai, and Pories, Walter J., and Chapman, William H. H., and Pender, John R., and Bowden, Rita C., and Reed, Melissa A., and Cortright, Ronald N., and Tapscott, Edward B., and Houmard, Joseph A., and Tanner, Charles J., and Lee, Jihyun, and Dohm, G. Lynis. "Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery". . . (.), December 2008. August 17, 2022. http://hdl.handle.net/10342/3220.
    Chicago:
    Bikman, Benjamin Thomas and Zheng, Donghai and Pories, Walter J. and Chapman, William H. H. and Pender, John R. and Bowden, Rita C. and Reed, Melissa A. and Cortright, Ronald N. and Tapscott, Edward B. and Houmard, Joseph A. and Tanner, Charles J. and Lee, Jihyun and Dohm, G. Lynis, "Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery,"  , no. (December 2008), http://hdl.handle.net/10342/3220 (accessed August 17, 2022).
    AMA:
    Bikman, Benjamin Thomas, Zheng, Donghai, Pories, Walter J., Chapman, William H. H., Pender, John R., Bowden, Rita C., Reed, Melissa A., Cortright, Ronald N., Tapscott, Edward B., Houmard, Joseph A., Tanner, Charles J., Lee, Jihyun, Dohm, G. Lynis. Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery. . December 2008; () . http://hdl.handle.net/10342/3220. Accessed August 17, 2022.
    Collections
    • Physiology
    • Surgery
    Publisher
    East Carolina University

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