• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Academic Affairs
    • Thomas Harriot College of Arts and Sciences
    • Biology
    • View Item
    •   ScholarShip Home
    • Academic Affairs
    • Thomas Harriot College of Arts and Sciences
    • Biology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Adaptive evolution of genes underlying schizophrenia

    Thumbnail
    View/ Open
    Adaptive evolution genes schizophrenia.pdf (269.1Kb)

    Show full item record
    
    Author
    Crespi, Bernard; Summers, Kyle; Dorus, Steve
    Abstract
    Schizophrenia poses an evolutionary-genetic paradox because it exhibits strongly negative fitness effects and high heritability, yet it persists at a prevalence of approximately 1% across all human cultures. Recent theory has proposed a resolution: that genetic liability to schizophrenia has evolved as a secondary consequence of selection for human cognitive traits. This hypothesis predicts that genes increasing the risk of this disorder have been subject to positive selection in the evolutionary history of humans and other primates. We evaluated this prediction using tests for recent selective sweeps in human populations and maximum-likelihood tests for selection during primate evolution. Significant evidence for positive selection was evident using one or both methods for 28 of 76 genes demonstrated to mediate liability to schizophrenia, including DISC1, DTNBP1 and NRG1, which exhibit especially strong and well-replicated functional and genetic links to this disorder. Strong evidence of non-neutral, accelerated evolution was found for DISC1, particularly for exon 2, the only coding region within the schizophrenia-associated haplotype. Additionally, genes associated with schizophrenia exhibited a statistically significant enrichment in their signals of positive selection in HapMap and PAML analyses of evolution along the human lineage, when compared with a control set of genes involved in neuronal activities. The selective forces underlying adaptive evolution of these genes remain largely unknown, but these findings provide convergent evidence consistent with the hypothesis that schizophrenia represents, in part, a maladaptive by-product of adaptive changes during human evolution. Originally published Proceedings of the Royal Society B, Vol. 274, No. 1627, Nov 2007
    URI
    http://hdl.handle.net/10342/3226
    Subject
     Adaptive evolution; Schizophrenia; Positive Darwinian selection; Disease genetics 
    Date
    2007-11-22
    Citation:
    APA:
    Crespi, Bernard, & Summers, Kyle, & Dorus, Steve. (November 2007). Adaptive evolution of genes underlying schizophrenia. Proceedings of the Royal Society B, (274:1627), p.2801-2810. Retrieved from http://hdl.handle.net/10342/3226

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Crespi, Bernard, and Summers, Kyle, and Dorus, Steve. "Adaptive evolution of genes underlying schizophrenia". Proceedings of the Royal Society B. 274:1627. (2801-2810.), November 2007. August 16, 2022. http://hdl.handle.net/10342/3226.
    Chicago:
    Crespi, Bernard and Summers, Kyle and Dorus, Steve, "Adaptive evolution of genes underlying schizophrenia," Proceedings of the Royal Society B 274, no. 1627 (November 2007), http://hdl.handle.net/10342/3226 (accessed August 16, 2022).
    AMA:
    Crespi, Bernard, Summers, Kyle, Dorus, Steve. Adaptive evolution of genes underlying schizophrenia. Proceedings of the Royal Society B. November 2007; 274(1627) 2801-2810. http://hdl.handle.net/10342/3226. Accessed August 16, 2022.
    Collections
    • Biology
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback