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    Statins induce lethal effects in acute myeloblastic lymphoma cells within 72 hours

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    Author
    Burke, Lillian P.; Kukoly, Cynthia A.
    Abstract
    HMG-CoA Reductase inhibitors (statins) induce apoptosis in acute myeloid leukemia (AML) cells in vitro; however, the concentrations associated with cell death in AML cells are higher than those clinically tolerated during prolonged therapy. We therefore wished to determine whether short exposures to lovastatin might induce cell death in AML cells at clinically attainable concentrations. The time and concentration dependence of HL60 and U937 cells was determined and showed that cell death was delayed. IC50 values and IC90 values determined on day 6 suggested that the sensitivity of AML cells to statins may occur at lower concentrations than previously reported. After 72 h, mevalonate did not rescue AML cells from cytotoxic concentrations of statins, suggesting that, although cell death was delayed, lovastatin induced lethal effects within 72 h. In conjunction with previously reported Phase I studies, the data presented here suggest that the high-dose, short course statins may be useful for the treatment of patients with AML. Originally published Leukemia and Lymphoma, Vol. 49, No. 2, Feb 2008
    URI
    http://hdl.handle.net/10342/3232
    Subject
     Acute myeloid leukemia; Statins; HMG CoA reductase inhibitors; Drug studies; Leukemic cell lines; HL60 cells; U937 cells 
    Date
    2008-02
    Citation:
    APA:
    Burke, Lillian P., & Kukoly, Cynthia A.. (February 2008). Statins induce lethal effects in acute myeloblastic lymphoma cells within 72 hours. , (. Retrieved from http://hdl.handle.net/10342/3232

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Burke, Lillian P., and Kukoly, Cynthia A.. "Statins induce lethal effects in acute myeloblastic lymphoma cells within 72 hours". . . (.), February 2008. February 28, 2021. http://hdl.handle.net/10342/3232.
    Chicago:
    Burke, Lillian P. and Kukoly, Cynthia A., "Statins induce lethal effects in acute myeloblastic lymphoma cells within 72 hours,"  , no. (February 2008), http://hdl.handle.net/10342/3232 (accessed February 28, 2021).
    AMA:
    Burke, Lillian P., Kukoly, Cynthia A.. Statins induce lethal effects in acute myeloblastic lymphoma cells within 72 hours. . February 2008; () . http://hdl.handle.net/10342/3232. Accessed February 28, 2021.
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    • Internal Medicine
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    East Carolina University

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