Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex
Author
Busija, David W.; Bari, Ferenc; Domoki, Ferenc; Louis, Thomas
Abstract
Glutamate and its synthetic analogues N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tight coupling between increased neural activity and cerebral blood flow. However, mechanisms involved in promoting cerebral vasodilator responses to glutamatergic agents are controversial. Here we review the development and current status of this important field of research especially in respect to cerebrovascular responses to NMDA receptor activation. Originally published Brain Research Review, Vol. 56, No. 1, Nov 2007
Date
2007-11
Citation:
APA:
Busija, David W., & Bari, Ferenc, & Domoki, Ferenc, & Louis, Thomas. (November 2007).
Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex.
Brain Research Reviews,
56(1),
89-
100. Retrieved from
http://hdl.handle.net/10342/3234
MLA:
Busija, David W., and Bari, Ferenc, and Domoki, Ferenc, and Louis, Thomas.
"Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex". Brain Research Reviews.
56:1. (89-100),
November 2007.
December 11, 2023.
http://hdl.handle.net/10342/3234.
Chicago:
Busija, David W. and Bari, Ferenc and Domoki, Ferenc and Louis, Thomas,
"Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex," Brain Research Reviews 56, no.
1 (November 2007),
http://hdl.handle.net/10342/3234 (accessed
December 11, 2023).
AMA:
Busija, David W., Bari, Ferenc, Domoki, Ferenc, Louis, Thomas.
Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex. Brain Research Reviews.
November 2007;
56(1):
89-100.
http://hdl.handle.net/10342/3234. Accessed
December 11, 2023.
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Publisher
East Carolina University