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    Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex

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    Author
    Busija, David W.; Bari, Ferenc; Domoki, Ferenc; Louis, Thomas
    Abstract
    Glutamate and its synthetic analogues N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tight coupling between increased neural activity and cerebral blood flow. However, mechanisms involved in promoting cerebral vasodilator responses to glutamatergic agents are controversial. Here we review the development and current status of this important field of research especially in respect to cerebrovascular responses to NMDA receptor activation. Originally published Brain Research Review, Vol. 56, No. 1, Nov 2007
    URI
    http://hdl.handle.net/10342/3234
    Subject
     Glutamate; Cerebral circulation; Cerebral arteries; Nitric Oxide; Neurons; Ischemia; N-methyl-D-aspartate receptors; Rats; Rabbits; Piglets 
    Date
    2007-11
    Citation:
    APA:
    Busija, David W., & Bari, Ferenc, & Domoki, Ferenc, & Louis, Thomas. (November 2007). Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex. Brain Research Reviews, 56(1), 89- 100. Retrieved from http://hdl.handle.net/10342/3234

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Busija, David W., and Bari, Ferenc, and Domoki, Ferenc, and Louis, Thomas. "Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex". Brain Research Reviews. 56:1. (89-100), November 2007. December 11, 2023. http://hdl.handle.net/10342/3234.
    Chicago:
    Busija, David W. and Bari, Ferenc and Domoki, Ferenc and Louis, Thomas, "Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex," Brain Research Reviews 56, no. 1 (November 2007), http://hdl.handle.net/10342/3234 (accessed December 11, 2023).
    AMA:
    Busija, David W., Bari, Ferenc, Domoki, Ferenc, Louis, Thomas. Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex. Brain Research Reviews. November 2007; 56(1): 89-100. http://hdl.handle.net/10342/3234. Accessed December 11, 2023.
    Collections
    • Pharmacology and Toxicology
    Publisher
    East Carolina University

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