Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex

Thumbnail Image

Files

Mechanism involved cerebrovascular dilator.pdf (570.47 KB)

Date

2007-11

Access

Authors

Busija, David W.
Bari, Ferenc
Domoki, Ferenc
Louis, Thomas

Journal Title

Journal ISSN

Volume Title

Publisher

East Carolina University

Abstract

Glutamate and its synthetic analogues N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tight coupling between increased neural activity and cerebral blood flow. However, mechanisms involved in promoting cerebral vasodilator responses to glutamatergic agents are controversial. Here we review the development and current status of this important field of research especially in respect to cerebrovascular responses to NMDA receptor activation. Originally published Brain Research Review, Vol. 56, No. 1, Nov 2007

Description

Keywords

Glutamate , Cerebral circulation , Cerebral arteries , Nitric Oxide , Neurons , Ischemia , N-methyl-D-aspartate receptors , Rats , Rabbits , Piglets

Citation

Brain Research Reviews; 56:1 p. 89-100

DOI

10.1016/j.brainresrev.2007.05.011

URI

http://hdl.handle.net/10342/3234

Collections

Pharmacology and Toxicology