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    Familial cryptic translocation resulting in Angelman syndrome:implications for imprinting or location of the Angelman gene?

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    Author
    Burke, Leah W.; Wiley, John E.; Glenn, Christopher C.; Driscoll, Daniel J.; Loud, Kenneth M.; Smith, April J. W.; Kushnick, Theodore
    Abstract
    Angelman syndrome (AS) is associated with a loss of maternal genetic information, which typically occurs as a result of a deletion at 15ql1-q13 or paternal uniparental disomy of chromosome 15. We report a patient with AS as a result of an unbalanced cryptic translocation whose breakpoint, at 15q11.2, falls within this region. The proband was diagnosed clinically as having Angelman syndrome, but without a detectable cytogenetic deletion, by using high-resolution G-banding. FISH detected a deletion of D15S11 (IR4-3R), with an intact GABRB3 locus. Subsequent studies of the proband's mother and sister detected a cryptic reciprocal translocation between chromosomes 14 and 15 with the breakpoint being between SNRPN and D15S1O (3-21). The proband was found to have inherited an unbalanced form, being monosomic from 15pter through SNRPN and trisomic for 14pter to 14q11.2. DNA methylation studies showed that the proband had a paternal-only DNA methylation pattern at SNRPN, D15S63 (PW71), and ZNF127. The mother and unaffected sister, both having the balanced translocation, demonstrated normal DNA methylation patterns at all three loci. These data suggest that the gene for AS most likely lies proximal to D15S1O, in contrast to the previously published position, although a less likely possibility is that the maternally inherited imprinting center acts in trans in the unaffected balanced translocation carrier sister. Originally published American Journal of Human Genetics, Vol. 58, No. 4, Apr 1996
    URI
    http://hdl.handle.net/10342/3244
    Subject
     Angelman syndrome; Cryptic translocation; AS gene location 
    Date
    1996-04
    Citation:
    APA:
    Burke, Leah W., & Wiley, John E., & Glenn, Christopher C., & Driscoll, Daniel J., & Loud, Kenneth M., & Smith, April J. W., & Kushnick, Theodore. (April 1996). Familial cryptic translocation resulting in Angelman syndrome:implications for imprinting or location of the Angelman gene?. American Journal of Human Genetics, (58:4), p.777-784. Retrieved from http://hdl.handle.net/10342/3244

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Burke, Leah W., and Wiley, John E., and Glenn, Christopher C., and Driscoll, Daniel J., and Loud, Kenneth M., and Smith, April J. W., and Kushnick, Theodore. "Familial cryptic translocation resulting in Angelman syndrome:implications for imprinting or location of the Angelman gene?". American Journal of Human Genetics. 58:4. (777-784.), April 1996. March 04, 2021. http://hdl.handle.net/10342/3244.
    Chicago:
    Burke, Leah W. and Wiley, John E. and Glenn, Christopher C. and Driscoll, Daniel J. and Loud, Kenneth M. and Smith, April J. W. and Kushnick, Theodore, "Familial cryptic translocation resulting in Angelman syndrome:implications for imprinting or location of the Angelman gene?," American Journal of Human Genetics 58, no. 4 (April 1996), http://hdl.handle.net/10342/3244 (accessed March 04, 2021).
    AMA:
    Burke, Leah W., Wiley, John E., Glenn, Christopher C., Driscoll, Daniel J., Loud, Kenneth M., Smith, April J. W., Kushnick, Theodore. Familial cryptic translocation resulting in Angelman syndrome:implications for imprinting or location of the Angelman gene?. American Journal of Human Genetics. April 1996; 58(4) 777-784. http://hdl.handle.net/10342/3244. Accessed March 04, 2021.
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    • Pediatrics
    Publisher
    East Carolina University

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