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    Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats

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    Author
    El-Mas, Mahmoud M.; Abdel-Rahman, Abdel A.
    Abstract
    Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses elicited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in telemetered female rats. Main methods—The effects of α-methyldopa or rilmenidine on blood pressure (BP), heart rate (HR) and their variability were investigated in rats that received liquid diet without or with ethanol (5% w/v) for 12 weeks. To evaluate the effect of each drug on cardiovascular autonomic control (BP and HR variability) in the absence or presence of ethanol, three time-domain indices of hemodynamic variability were measured: (i) standard deviation of mean arterial pressure (SDMAP), (ii) standard deviation of beat-to-beat intervals, and (iii) root mean square of successive differences in R-R intervals. Key findings—In liquid diet-fed control rats, i.p. rilmenidine (600 μg/kg) or α-methyldopa (100 mg/kg) reduced BP along with decreases and increases, respectively, in HR. Both drugs had no effect on HR variability but reduced BP variability (SDMAP), suggesting a reduced vasomotor sympathetic tone. Ethanol feeding attenuated reductions in BP and SDMAP evoked by α-methyldopa but not by rilmenidine. Significance—We conclude that chronic ethanol preferentially compromises α2- but not I1- receptor-mediated hypotension in female rats probably via modulation of vasomotor sympathetic activity. These findings highlight the adequacy of rilmenidine use to lower BP in hypertensive alcoholic females.
    URI
    http://hdl.handle.net/10342/3260
    Subject
     Ethanol; Rilmenidine; Alpha-methyldopa; Hypotension; Females; Rats 
    Date
    2009-01-16
    Citation:
    APA:
    El-Mas, Mahmoud M., & Abdel-Rahman, Abdel A.. (January 2009). Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats. Life Sciences, (84:3-4), p.111-118. Retrieved from http://hdl.handle.net/10342/3260

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    El-Mas, Mahmoud M., and Abdel-Rahman, Abdel A.. "Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats". Life Sciences. 84:3-4. (111-118.), January 2009. March 08, 2021. http://hdl.handle.net/10342/3260.
    Chicago:
    El-Mas, Mahmoud M. and Abdel-Rahman, Abdel A., "Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats," Life Sciences 84, no. 3-4 (January 2009), http://hdl.handle.net/10342/3260 (accessed March 08, 2021).
    AMA:
    El-Mas, Mahmoud M., Abdel-Rahman, Abdel A.. Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats. Life Sciences. January 2009; 84(3-4) 111-118. http://hdl.handle.net/10342/3260. Accessed March 08, 2021.
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    • Anatomy and Cell Biology
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    East Carolina University

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