Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats
Author
El-Mas, Mahmoud M.; Abdel-Rahman, Abdel A.
Abstract
Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses
elicited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in
telemetered female rats.
Main methods—The effects of α-methyldopa or rilmenidine on blood pressure (BP), heart rate
(HR) and their variability were investigated in rats that received liquid diet without or with ethanol
(5% w/v) for 12 weeks. To evaluate the effect of each drug on cardiovascular autonomic control (BP
and HR variability) in the absence or presence of ethanol, three time-domain indices of hemodynamic
variability were measured: (i) standard deviation of mean arterial pressure (SDMAP), (ii) standard
deviation of beat-to-beat intervals, and (iii) root mean square of successive differences in R-R
intervals.
Key findings—In liquid diet-fed control rats, i.p. rilmenidine (600 μg/kg) or α-methyldopa (100
mg/kg) reduced BP along with decreases and increases, respectively, in HR. Both drugs had no effect
on HR variability but reduced BP variability (SDMAP), suggesting a reduced vasomotor sympathetic
tone. Ethanol feeding attenuated reductions in BP and SDMAP evoked by α-methyldopa but not by
rilmenidine.
Significance—We conclude that chronic ethanol preferentially compromises α2- but not I1-
receptor-mediated hypotension in female rats probably via modulation of vasomotor sympathetic
activity. These findings highlight the adequacy of rilmenidine use to lower BP in hypertensive
alcoholic females.
Subject
Date
2009-01-16
Citation:
APA:
El-Mas, Mahmoud M., & Abdel-Rahman, Abdel A.. (January 2009).
Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats.
Life Sciences,
84(3-4),
111-
4 p. 111-118. Retrieved from
http://hdl.handle.net/10342/3260
MLA:
El-Mas, Mahmoud M., and Abdel-Rahman, Abdel A..
"Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats". Life Sciences.
84:3-4. (111-118),
January 2009.
June 29, 2024.
http://hdl.handle.net/10342/3260.
Chicago:
El-Mas, Mahmoud M. and Abdel-Rahman, Abdel A.,
"Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats," Life Sciences 84, no.
3-4 (January 2009),
http://hdl.handle.net/10342/3260 (accessed
June 29, 2024).
AMA:
El-Mas, Mahmoud M., Abdel-Rahman, Abdel A..
Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats. Life Sciences.
January 2009;
84(3-4):
111-118.
http://hdl.handle.net/10342/3260. Accessed
June 29, 2024.
Collections
Publisher
East Carolina University