Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
Author
Fairbanks, Carolyn A.; Schreiber, Kristin L.; Brewer, Kori L.; Yu, Chen-Guang; Stone, Laura S.; Kitto, Kelley F.; Nguyen, H. Oanh; Grocholski, Brent M.; Shoeman, Don W.; Kehl, Lois J.; Regunathan, Soundararajan; Reis, Donald J.; Yezierski, Robert P.; Wilcox, George L.
Abstract
Antagonists of glutamate receptors of the N-methyl-D-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting a clinical opportunity for the use of NMDAR antagonists and NOS inhibitors in chronic pain. Agmatine (AG), an endogenous neuromodulator present in brain and spinal cord, has both NMDAR antagonist and NOS inhibitor activities. We report here that AG, exogenously administered to rodents, decreased hyperalgesia accompanying inflammation, normalized the mechanical hypersensitivity (allodyniayhyperalgesia) produced by chemical or mechanical nerve injury, and reduced autotomy-like behavior and lesion size after excitotoxic spinal cord injury. AG produced these effects in the absence of antinociceptive effects in acute pain tests. Endogenous AG also was detected in rodent lumbosacral spinal cord in concentrations similar to those previously detected in brain. The evidence suggests a unique antiplasticity and neuroprotective role for AG in processes underlying persistent pain and neuronal injury. Originally published Proceedings of the National Academy of Sciences, Vol. 97, No. 19, Sep 2000
Date
2000-09-12
Citation:
APA:
Fairbanks, Carolyn A., & Schreiber, Kristin L., & Brewer, Kori L., & Yu, Chen-Guang, & Stone, Laura S., & Kitto, Kelley F., & Nguyen, H. Oanh, & Grocholski, Brent M., & Shoeman, Don W., & Kehl, Lois J., & Regunathan, Soundararajan, & Reis, Donald J., & Yezierski, Robert P., & Wilcox, George L.. (September 2000).
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury.
Proceedings of the National Academy of Sciences,
97(19),
10584-
10589. Retrieved from
http://hdl.handle.net/10342/3273
MLA:
Fairbanks, Carolyn A., and Schreiber, Kristin L., and Brewer, Kori L., and Yu, Chen-Guang, and Stone, Laura S., and Kitto, Kelley F., and Nguyen, H. Oanh, and Grocholski, Brent M., and Shoeman, Don W., and Kehl, Lois J., and Regunathan, Soundararajan, and Reis, Donald J., and Yezierski, Robert P., and Wilcox, George L..
"Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury". Proceedings of the National Academy of Sciences.
97:19. (10584-10589),
September 2000.
December 04, 2023.
http://hdl.handle.net/10342/3273.
Chicago:
Fairbanks, Carolyn A. and Schreiber, Kristin L. and Brewer, Kori L. and Yu, Chen-Guang and Stone, Laura S. and Kitto, Kelley F. and Nguyen, H. Oanh and Grocholski, Brent M. and Shoeman, Don W. and Kehl, Lois J. and Regunathan, Soundararajan and Reis, Donald J. and Yezierski, Robert P. and Wilcox, George L.,
"Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury," Proceedings of the National Academy of Sciences 97, no.
19 (September 2000),
http://hdl.handle.net/10342/3273 (accessed
December 04, 2023).
AMA:
Fairbanks, Carolyn A., Schreiber, Kristin L., Brewer, Kori L., Yu, Chen-Guang, Stone, Laura S., Kitto, Kelley F., Nguyen, H. Oanh, Grocholski, Brent M., Shoeman, Don W., Kehl, Lois J., Regunathan, Soundararajan, Reis, Donald J., Yezierski, Robert P., Wilcox, George L..
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proceedings of the National Academy of Sciences.
September 2000;
97(19):
10584-10589.
http://hdl.handle.net/10342/3273. Accessed
December 04, 2023.
Collections
Publisher
East Carolina University