PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function
Author
Fooksman, David Robert; Shaikh, Saame Raza; Boyle, Sarah; Edidin, Michael
Abstract
Little is known about the signaling that occurs in an antigen presenting cell (APC) during contact with a T cell. Here we report the concentration of the signaling lipid, PI(4,5)P2, at the APC side of the immunological synapse. In both human and mouse cells, a PI(4,5)P2-specific fluorescent reporter, PH-GFP, detected an antigen-dependent enrichment of PI(4,5)P2 at the synapse between antigen- specific T cells and APC. When PIP(4,5)P2 was sequestered by a high concentration of PH-GFP reporter, cells were less susceptible to CTL-mediated lysis than control cells. These findings suggest a new regulatory target for modulating immune function that may be exploited for immune escape by pathogens and tumors. Originally published Journal of Immunology, Vol. 182, No. 9, May 2009
Subject
Date
2009-05-01
Citation:
APA:
Fooksman, David Robert, & Shaikh, Saame Raza, & Boyle, Sarah, & Edidin, Michael. (May 2009).
PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function.
Journal of Immunology,
182(9),
5179-
5182. Retrieved from
http://hdl.handle.net/10342/3276
MLA:
Fooksman, David Robert, and Shaikh, Saame Raza, and Boyle, Sarah, and Edidin, Michael.
"PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function". Journal of Immunology.
182:9. (5179-5182),
May 2009.
September 25, 2023.
http://hdl.handle.net/10342/3276.
Chicago:
Fooksman, David Robert and Shaikh, Saame Raza and Boyle, Sarah and Edidin, Michael,
"PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function," Journal of Immunology 182, no.
9 (May 2009),
http://hdl.handle.net/10342/3276 (accessed
September 25, 2023).
AMA:
Fooksman, David Robert, Shaikh, Saame Raza, Boyle, Sarah, Edidin, Michael.
PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function. Journal of Immunology.
May 2009;
182(9):
5179-5182.
http://hdl.handle.net/10342/3276. Accessed
September 25, 2023.
Collections
Publisher
East Carolina University