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    PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function

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    Author
    Fooksman, David Robert; Shaikh, Saame Raza; Boyle, Sarah; Edidin, Michael
    Abstract
    Little is known about the signaling that occurs in an antigen presenting cell (APC) during contact with a T cell. Here we report the concentration of the signaling lipid, PI(4,5)P2, at the APC side of the immunological synapse. In both human and mouse cells, a PI(4,5)P2-specific fluorescent reporter, PH-GFP, detected an antigen-dependent enrichment of PI(4,5)P2 at the synapse between antigen- specific T cells and APC. When PIP(4,5)P2 was sequestered by a high concentration of PH-GFP reporter, cells were less susceptible to CTL-mediated lysis than control cells. These findings suggest a new regulatory target for modulating immune function that may be exploited for immune escape by pathogens and tumors. Originally published Journal of Immunology, Vol. 182, No. 9, May 2009
    URI
    http://hdl.handle.net/10342/3276
    Subject
     Cytotoxicity; T cells cytotoxic; MHC; Antigen Presentation 
    Date
    2009-05-01
    Citation:
    APA:
    Fooksman, David Robert, & Shaikh, Saame Raza, & Boyle, Sarah, & Edidin, Michael. (May 2009). PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function. Journal of Immunology, 182(9), 5179- 5182. Retrieved from http://hdl.handle.net/10342/3276

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Fooksman, David Robert, and Shaikh, Saame Raza, and Boyle, Sarah, and Edidin, Michael. "PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function". Journal of Immunology. 182:9. (5179-5182), May 2009. September 25, 2023. http://hdl.handle.net/10342/3276.
    Chicago:
    Fooksman, David Robert and Shaikh, Saame Raza and Boyle, Sarah and Edidin, Michael, "PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function," Journal of Immunology 182, no. 9 (May 2009), http://hdl.handle.net/10342/3276 (accessed September 25, 2023).
    AMA:
    Fooksman, David Robert, Shaikh, Saame Raza, Boyle, Sarah, Edidin, Michael. PI(4,5)P2 concentration at the APC side of the Immunological Synapse is Required for Effector T cell Function. Journal of Immunology. May 2009; 182(9): 5179-5182. http://hdl.handle.net/10342/3276. Accessed September 25, 2023.
    Collections
    • Microbiology and Immunology
    Publisher
    East Carolina University

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