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    Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats

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    Author
    Farraj, Aimen K.; Haykal-Coates, Najwa; Winsett, Darrell W.; Hazari, Medhi S.; Carll, Alex P.; Rowan, William H. III; Ledbetter, Allen D.; Cascio, Wayne E.; Costa, Daniel L.
    Abstract
    Background: Exposure to combustion-derived fine particulate matter (PM) is associated with increased cardiovascular morbidity and mortality especially in individuals with cardiovascular disease, including hypertension. PM inhalation causes several adverse changes in cardiac function that are reflected in the electrocardiogram (ECG), including altered cardiac rhythm, myocardial ischemia, and reduced heart rate variability (HRV). The sensitivity and reliability of ECG-derived parameters as indicators of the cardiovascular toxicity of PM in rats are unclear. Objective: We hypothesized that spontaneously hypertensive (SH) rats are more susceptible to the development of PM-induced arrhythmia, altered ECG morphology, and reduced HRV than are Wistar Kyoto (WKY) rats, a related strain with normal blood pressure. Methods: We exposed rats once by nose-only inhalation for 4 hr to residual oil fly ash (ROFA), an emission source particle rich in transition metals, or to air and then sacrificed them 1 or 48 hr later. Results: ROFA-exposed SH rats developed nonconducted P-wave arrhythmias but no changes in ECG morphology or HRV. We found no ECG effects in ROFA-exposed WKY rats. ROFA-exposed SH rats also had greater pulmonary injury, neutrophil infiltration, and serum C-reactive protein than did ROFA-exposed WKY rats. Conclusions: These results suggest that cardiac arrhythmias may be an early sensitive indicator of the propensity for PM inhalation to modify cardiovascular function. Originally published Environmental Health Perspectives, Vol. 117, No. 5, May 2009
    URI
    http://hdl.handle.net/10342/3277
    Subject
     Arrhythmia; Electrocardiogram; Heart rate variability; Hypertension; Inhalation; Nonconducted P-waves; Particulate matter; Rats; Residual oil fly ash 
    Date
    2009-05
    Citation:
    APA:
    Farraj, Aimen K., & Haykal-Coates, Najwa, & Winsett, Darrell W., & Hazari, Medhi S., & Carll, Alex P., & Rowan, William H. III, & Ledbetter, Allen D., & Cascio, Wayne E., & Costa, Daniel L.. (May 2009). Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats. Environmental Health Perspectives, (117:5), p.709-715. Retrieved from http://hdl.handle.net/10342/3277

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    MLA:
    Farraj, Aimen K., and Haykal-Coates, Najwa, and Winsett, Darrell W., and Hazari, Medhi S., and Carll, Alex P., and Rowan, William H. III, and Ledbetter, Allen D., and Cascio, Wayne E., and Costa, Daniel L.. "Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats". Environmental Health Perspectives. 117:5. (709-715.), May 2009. March 04, 2021. http://hdl.handle.net/10342/3277.
    Chicago:
    Farraj, Aimen K. and Haykal-Coates, Najwa and Winsett, Darrell W. and Hazari, Medhi S. and Carll, Alex P. and Rowan, William H. III and Ledbetter, Allen D. and Cascio, Wayne E. and Costa, Daniel L., "Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats," Environmental Health Perspectives 117, no. 5 (May 2009), http://hdl.handle.net/10342/3277 (accessed March 04, 2021).
    AMA:
    Farraj, Aimen K., Haykal-Coates, Najwa, Winsett, Darrell W., Hazari, Medhi S., Carll, Alex P., Rowan, William H. III, Ledbetter, Allen D., Cascio, Wayne E., Costa, Daniel L.. Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats. Environmental Health Perspectives. May 2009; 117(5) 709-715. http://hdl.handle.net/10342/3277. Accessed March 04, 2021.
    Collections
    • Cardiovascular Sciences
    Publisher
    East Carolina University

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