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    Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa

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    Author
    Gallagher, Larry A.; McKnight, Susan L.; Kuznetsova, Marina S.; Pesci, Everett C.; Manoil, Colin
    Abstract
    A set of 30 mutants exhibiting reduced production of the phenazine poison pyocyanin were isolated following transposon mutagenesis of Pseudomonas aeruginosa PAO1. The mutants could be subdivided into those with defects in the primary phenazine biosynthetic pathway and those with more pleiotropic defects. The largest set of pleiotropic mutations blocked the production of the extracellular Pseudomonas quinolone signal (PQS), a molecule required for the synthesis of secondary metabolites and extracellular enzymes. Most of these pqs mutations affected genes which appear to encode PQS biosynthetic functions, although a transcriptional regulator and an apparent response effector were also represented. Two of the genes required for PQS synthesis (phnA and phnB) had previously been assumed to encode phenazine biosynthetic functions. The transcription of one of the genes required for PQS synthesis (PA2587/pqsH) was regulated by the LasI/R quorum-sensing system, thereby linking quorum sensing and PQS regulation. Others of the pleiotropic phenazine-minus mutations appear to inactivate novel components of the quorum-sensing regulatory network, including one regulator (np20) previously shown to be required for virulence in neutropenic mice. Originally published Journal of Bacteriology, Vol. 184, No. 23, Dec 2002
    URI
    http://hdl.handle.net/10342/3288
    Subject
     Pseudomonas aeruginosa; Quinolone signaling; Phenazine biosynthetic pathway 
    Date
    2002-12
    Citation:
    APA:
    Gallagher, Larry A., & McKnight, Susan L., & Kuznetsova, Marina S., & Pesci, Everett C., & Manoil, Colin. (December 2002). Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa. Journal of Bacteriology, (184:23), p.6472-6480. Retrieved from http://hdl.handle.net/10342/3288

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Gallagher, Larry A., and McKnight, Susan L., and Kuznetsova, Marina S., and Pesci, Everett C., and Manoil, Colin. "Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa". Journal of Bacteriology. 184:23. (6472-6480.), December 2002. April 21, 2021. http://hdl.handle.net/10342/3288.
    Chicago:
    Gallagher, Larry A. and McKnight, Susan L. and Kuznetsova, Marina S. and Pesci, Everett C. and Manoil, Colin, "Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa," Journal of Bacteriology 184, no. 23 (December 2002), http://hdl.handle.net/10342/3288 (accessed April 21, 2021).
    AMA:
    Gallagher, Larry A., McKnight, Susan L., Kuznetsova, Marina S., Pesci, Everett C., Manoil, Colin. Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosa. Journal of Bacteriology. December 2002; 184(23) 6472-6480. http://hdl.handle.net/10342/3288. Accessed April 21, 2021.
    Collections
    • Microbiology and Immunology
    Publisher
    East Carolina University

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