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    Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.

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    Author
    Kern, Marialice; Wells, James A.; Stephens, Jacqueline M.; Elton, Charles W.; Friedman, Jacob E.; Tapscott, Edward B.; Pekala, Phillip H.; Dohm, G. Lynis
    Abstract
    Glucose transport in skeletal muscle is mediated by two distinct transporter isoforms, designated muscle/adipose glucose transporter (Glut4) and erythrocyte/HepG2/brain glucose transporter (Glutl), which differ in both abundance and membrane distribution. The present study was designed to investigate whether differences in insulin responsiveness of red and white muscle might be due to differential expression of the glucose transporter isoforms. Glucose transport, as well as Glutl and Glut4 protein and mRNA levels, were determined in red and white portions of the quadriceps and gastrocnemius muscles of male Sprague-Dawley rats (body wt. approx. 250 g). Maximal glucose transport (in response to 100 nM-insulin) in the perfused hindlimb was 3.6 times greater in red than in white muscle. Red muscle contained approx. 5 times more total Glut4 protein and 2 times more Glut4 mRNA than white muscle, but there were no differences in the Glutl protein or mRNA levels between the fibre types. Our data indicate that differences in responsiveness of glucose transport in specific skeletal muscle fibre types may be dependent upon the amount of Glut4 protein. Because this protein plays such an integral part in glucose transport in skeletal muscle, any impairment in its expression may play a role in insulin resistance. Originally published Biochemical Journal, Vol. 270, No. 2, Sep 1990
    URI
    http://hdl.handle.net/10342/3308
    Subject
     Skeletal muscle; Glut4; Glut1; Insulin resistance 
    Date
    1990-09-01
    Citation:
    APA:
    Kern, Marialice, & Wells, James A., & Stephens, Jacqueline M., & Elton, Charles W., & Friedman, Jacob E., & Tapscott, Edward B., & Pekala, Phillip H., & Dohm, G. Lynis. (September 1990). Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.. Biochemical Journal, (270:2), p.397-400. Retrieved from http://hdl.handle.net/10342/3308

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    MLA:
    Kern, Marialice, and Wells, James A., and Stephens, Jacqueline M., and Elton, Charles W., and Friedman, Jacob E., and Tapscott, Edward B., and Pekala, Phillip H., and Dohm, G. Lynis. "Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.". Biochemical Journal. 270:2. (397-400.), September 1990. March 06, 2021. http://hdl.handle.net/10342/3308.
    Chicago:
    Kern, Marialice and Wells, James A. and Stephens, Jacqueline M. and Elton, Charles W. and Friedman, Jacob E. and Tapscott, Edward B. and Pekala, Phillip H. and Dohm, G. Lynis, "Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.," Biochemical Journal 270, no. 2 (September 1990), http://hdl.handle.net/10342/3308 (accessed March 06, 2021).
    AMA:
    Kern, Marialice, Wells, James A., Stephens, Jacqueline M., Elton, Charles W., Friedman, Jacob E., Tapscott, Edward B., Pekala, Phillip H., Dohm, G. Lynis. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.. Biochemical Journal. September 1990; 270(2) 397-400. http://hdl.handle.net/10342/3308. Accessed March 06, 2021.
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    • Biochemistry and Molecular Biology
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    East Carolina University

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