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    E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin

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    Author
    Kim, Hangun; Oh, Minsoo; Lu, Qun; Kim, Kwonseop
    Abstract
    δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins. Here, we describe distinctive features of δ-catenin localization and its association with E-cadherin in HEK293 epithelial cells. In HEK293 cells maintained in low cell densities, approximately 15% of cells overexpressing δ-catenin showed dendrite-like process formation, but there was no detectable change in RhoA activity. In addition, δ-catenin was localized mainly in the cytoplasm and was associated with p190RhoGEF. However, at high cell densities, δ-catenin localization was shifted to the plasma membrane. The association of δ-catenin with E-cadherin was strengthened, whereas its interaction with p190RhoGEF was weakened. In mouse embryonic fibroblast cell, ectopic expression of Ecadherin decreased the effect of δ-catenin on the reduction of RhoA activity as well as on dendritelike process formation. These results suggest that δ-catenin is more dominantly bound to E-cadherin than to p190RhoGEF, and that δ-catenin’s function is dependent on its cellular binding partner. Originally published Biochem Biophys Res Commun, Vol. 377, No. 2, Dec 2008
    URI
    http://hdl.handle.net/10342/3322
    Subject
     [Delta]-catenin; Cadherin; Dendrogenesis; Adherens junction; RhoA; δ-catenin 
    Date
    2008-12-12
    Citation:
    APA:
    Kim, Hangun, & Oh, Minsoo, & Lu, Qun, & Kim, Kwonseop. (December 2008). E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin. Biochemical and Biophysical Research Communications, (377:2), p.636-641. Retrieved from http://hdl.handle.net/10342/3322

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Kim, Hangun, and Oh, Minsoo, and Lu, Qun, and Kim, Kwonseop. "E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin". Biochemical and Biophysical Research Communications. 377:2. (636-641.), December 2008. March 02, 2021. http://hdl.handle.net/10342/3322.
    Chicago:
    Kim, Hangun and Oh, Minsoo and Lu, Qun and Kim, Kwonseop, "E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin," Biochemical and Biophysical Research Communications 377, no. 2 (December 2008), http://hdl.handle.net/10342/3322 (accessed March 02, 2021).
    AMA:
    Kim, Hangun, Oh, Minsoo, Lu, Qun, Kim, Kwonseop. E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin. Biochemical and Biophysical Research Communications. December 2008; 377(2) 636-641. http://hdl.handle.net/10342/3322. Accessed March 02, 2021.
    Collections
    • Pharmacology and Toxicology
    Publisher
    East Carolina University

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