Targeting prostate cancer based on signal transduction and cell cycle pathways

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Author
Lee, John T.; Lehmann, Brian D.; Terrian, David M.; Chappell, William H.; Stivala, Franca; Libra, Massimo; Martelli, Alberto M.; Steelman, Linda S.; McCubrey, James A.
Abstract
Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent, which often occurs after hormonal ablation therapies, it is difficult to effectively treat. Prostate cancer may arise from mutations and dysregulation of various genes involved in regulation signal transduction (e.g., PTEN, Akt, etc.,) and the cell cycle (e.g., p53, p21Cip1, p27Kip1, Rb, etc.,). This review focuses on the aberrant interactions of signal transduction and cell cycle genes products and how they can contribute to prostate cancer and alter therapeutic effectiveness. Originally published Cell Cycle, Vol. 7, No. 12, June 2008
URI
http://hdl.handle.net/10342/3339
Subject
 Radiosensitization; Prostate--Cancer; p53; MDM-2; Antagonists; Senescence; PTEN; Akt 
Date
2008-06-15
Citation:
APA:
Lee, John T., & Lehmann, Brian D., & Terrian, David M., & Chappell, William H., & Stivala, Franca, & Libra, Massimo, & Martelli, Alberto M., & Steelman, Linda S., & McCubrey, James A.. (June 2008). Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle, 7(12), 1745- 1762. Retrieved from http://hdl.handle.net/10342/3339

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MLA:
Lee, John T., and Lehmann, Brian D., and Terrian, David M., and Chappell, William H., and Stivala, Franca, and Libra, Massimo, and Martelli, Alberto M., and Steelman, Linda S., and McCubrey, James A.. "Targeting prostate cancer based on signal transduction and cell cycle pathways". Cell Cycle. 7:12. (1745-1762), June 2008. October 01, 2023. http://hdl.handle.net/10342/3339.
Chicago:
Lee, John T. and Lehmann, Brian D. and Terrian, David M. and Chappell, William H. and Stivala, Franca and Libra, Massimo and Martelli, Alberto M. and Steelman, Linda S. and McCubrey, James A., "Targeting prostate cancer based on signal transduction and cell cycle pathways," Cell Cycle 7, no. 12 (June 2008), http://hdl.handle.net/10342/3339 (accessed October 01, 2023).
AMA:
Lee, John T., Lehmann, Brian D., Terrian, David M., Chappell, William H., Stivala, Franca, Libra, Massimo, Martelli, Alberto M., Steelman, Linda S., McCubrey, James A.. Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle. June 2008; 7(12): 1745-1762. http://hdl.handle.net/10342/3339. Accessed October 01, 2023.
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Publisher
East Carolina University