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    Targeting prostate cancer based on signal transduction and cell cycle pathways

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    Author
    Lee, John T.; Lehmann, Brian D.; Terrian, David M.; Chappell, William H.; Stivala, Franca; Libra, Massimo; Martelli, Alberto M.; Steelman, Linda S.; McCubrey, James A.
    Abstract
    Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent, which often occurs after hormonal ablation therapies, it is difficult to effectively treat. Prostate cancer may arise from mutations and dysregulation of various genes involved in regulation signal transduction (e.g., PTEN, Akt, etc.,) and the cell cycle (e.g., p53, p21Cip1, p27Kip1, Rb, etc.,). This review focuses on the aberrant interactions of signal transduction and cell cycle genes products and how they can contribute to prostate cancer and alter therapeutic effectiveness. Originally published Cell Cycle, Vol. 7, No. 12, June 2008
    URI
    http://hdl.handle.net/10342/3339
    Subject
     Radiosensitization; Prostate--Cancer; p53; MDM-2; Antagonists; Senescence; PTEN; Akt 
    Date
    2008-06-15
    Citation:
    APA:
    Lee, John T., & Lehmann, Brian D., & Terrian, David M., & Chappell, William H., & Stivala, Franca, & Libra, Massimo, & Martelli, Alberto M., & Steelman, Linda S., & McCubrey, James A.. (June 2008). Targeting prostate cancer based on signal transduction and cell cycle pathways. , (. Retrieved from http://hdl.handle.net/10342/3339

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Lee, John T., and Lehmann, Brian D., and Terrian, David M., and Chappell, William H., and Stivala, Franca, and Libra, Massimo, and Martelli, Alberto M., and Steelman, Linda S., and McCubrey, James A.. "Targeting prostate cancer based on signal transduction and cell cycle pathways". . . (.), June 2008. February 26, 2021. http://hdl.handle.net/10342/3339.
    Chicago:
    Lee, John T. and Lehmann, Brian D. and Terrian, David M. and Chappell, William H. and Stivala, Franca and Libra, Massimo and Martelli, Alberto M. and Steelman, Linda S. and McCubrey, James A., "Targeting prostate cancer based on signal transduction and cell cycle pathways,"  , no. (June 2008), http://hdl.handle.net/10342/3339 (accessed February 26, 2021).
    AMA:
    Lee, John T., Lehmann, Brian D., Terrian, David M., Chappell, William H., Stivala, Franca, Libra, Massimo, Martelli, Alberto M., Steelman, Linda S., McCubrey, James A.. Targeting prostate cancer based on signal transduction and cell cycle pathways. . June 2008; () . http://hdl.handle.net/10342/3339. Accessed February 26, 2021.
    Collections
    • Microbiology and Immunology
    Publisher
    East Carolina University

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