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    Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats

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    Author
    Li, Guichu; Abdel-Rahman, Abdel A.
    Abstract
    Background- Our previous pharmacological and cellular studies showed that peripheral (cardiac and vascular) NOS-derived NO is implicated in the estrogen-dependent hypotensive action of ethanol in female rats. The objective of this study was to test the hypothesis that enhanced NO production in the nucleus tractus solitarius (NTS) is implicated in the estrogen-dependent hypotensive action of ethanol. Methods- To achieve this goal, we utilized in vivo electrochemistry to measure real time changes in neuronal NO to investigate the acute effects of intragastric ethanol (0, 0.5 or 1 g/kg) on NO in NTS neurons, blood pressure (BP) and heart rate (HR) in conscious female rats in the absence (ovariectomized, OVX, rats) or presence of estrogen. Results- In sham operated (SO) rats, ethanol elicited dose-related increase in NTS NO and reduction in BP. These neurochemical and blood pressure effects of ethanol were absent in OVX rats. Whether the neurochemical effect of ethanol and the associated hypotension are dependent on rapid estrogen signaling was investigated. In OVX rats pretreated, 30 min earlier, with estrogen (E2, ug/kg), intragastric ethanol (1 g/kg) increased NTS NO and reduced BP and these responses were comparable to those obtained in SO rats. Conclusions- The present findings suggest that increased production of NO in NTS neurons contributes to ethanol-evoked hypotension in female rats. Further, ethanol enhancement of neuronal NO production in the brainstem is dependent on rapid estrogen signaling. Originally published Alcohol: Clinical and Experimental Research, Vol. 33, No. 2, Feb 2009
    URI
    http://hdl.handle.net/10342/3342
    Subject
     Electrochemistry; NO; NTS; Ethanol; LPS; Conscious rats 
    Date
    2009-02
    Citation:
    APA:
    Li, Guichu, & Abdel-Rahman, Abdel A.. (February 2009). Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats. Alcoholism: Clinical and Experimental Research, (33:2), p.366-374. Retrieved from http://hdl.handle.net/10342/3342

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    MLA:
    Li, Guichu, and Abdel-Rahman, Abdel A.. "Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats". Alcoholism: Clinical and Experimental Research. 33:2. (366-374.), February 2009. March 03, 2021. http://hdl.handle.net/10342/3342.
    Chicago:
    Li, Guichu and Abdel-Rahman, Abdel A., "Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats," Alcoholism: Clinical and Experimental Research 33, no. 2 (February 2009), http://hdl.handle.net/10342/3342 (accessed March 03, 2021).
    AMA:
    Li, Guichu, Abdel-Rahman, Abdel A.. Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats. Alcoholism: Clinical and Experimental Research. February 2009; 33(2) 366-374. http://hdl.handle.net/10342/3342. Accessed March 03, 2021.
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    • Anatomy and Cell Biology
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    East Carolina University

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