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    Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells

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    Author
    Mendelev, Natalia N.; Williams, Verietta S.; Tulis, David A.
    Abstract
    Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases, and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has been generally considered protective in cardiac and vascular tissues and has been the target of numerous basic science and clinical studies. In this project, the influence of BAY 41-2272 (BAY), a recently described soluble guanylate cyclase (sGC) stimulator and inducer of cyclic guanosine monophosphate (cGMP) synthesis, on VSM cell growth was analyzed. In rat A7R5 VSM cells BAY significantly reduced proliferation in dose- and time-dependent fashion. BAY activated cGMP and cyclic adenosine monophosphate (cAMP) signaling evidenced through elevated cGMP and cAMP content, increased expression of cyclic nucleotide-dependent protein kinases, and differential vasodilator-stimulated phosphoprotein (VASP) phosphorylation. BAY significantly elevated cyclin E expression, decreased expression of the regulatory cyclin-dependent kinases (Cdk)-2 and -6, increased expression of cell cycle inhibitory p21WAF1/Cip1 and p27Kip1, and reduced expression of phosphorylated focal adhesion kinase (FAK). These comprehensive findings provide first evidence for the anti-growth, cell cycle-regulatory properties of the neoteric agent BAY 41-2272 in VSM and lend support for its continued study in the clinical and basic cardiovascular sciences. Originally published Journal of Cardiovascular Pharmacology, Vol. 53, No. 2, Feb 2009
    URI
    http://hdl.handle.net/10342/3354
    Subject
     BAY 41-2272; Cyclic GMP; Cyclins; Protein kinases; Vascular smooth muscle 
    Date
    2009-02
    Citation:
    APA:
    Mendelev, Natalia N., & Williams, Verietta S., & Tulis, David A.. (February 2009). Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells. Journal of Cardiovascular Pharmacology, (53:2), p.121-131. Retrieved from http://hdl.handle.net/10342/3354

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Mendelev, Natalia N., and Williams, Verietta S., and Tulis, David A.. "Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells". Journal of Cardiovascular Pharmacology. 53:2. (121-131.), February 2009. April 20, 2021. http://hdl.handle.net/10342/3354.
    Chicago:
    Mendelev, Natalia N. and Williams, Verietta S. and Tulis, David A., "Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells," Journal of Cardiovascular Pharmacology 53, no. 2 (February 2009), http://hdl.handle.net/10342/3354 (accessed April 20, 2021).
    AMA:
    Mendelev, Natalia N., Williams, Verietta S., Tulis, David A.. Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells. Journal of Cardiovascular Pharmacology. February 2009; 53(2) 121-131. http://hdl.handle.net/10342/3354. Accessed April 20, 2021.
    Collections
    • Physiology
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    East Carolina University

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