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    Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees

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    Author
    Moser, Kathy L.; Neas, Barbara R.; Salmon, Jane E.; Yu, Hua; Gray-McGuire, Courtney; Asundi, Neeraj; Bruner, Gail R.; Fox, Jerome; Kelly, Jennifer; Henshall, Stephanie; Bacino, Debra; Dietz, Myron; Hogue, Robert; Koelsch, Gerald; Nightingale, Lydia; Shaver, Tim; Abdou, Nabih I.; Albert, Daniel A.; Carson, Craig; Petri, Michelle; Treadwell, Edward L.; James, Judith A.; Harley, John B.
    Abstract
    Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is suspected to involve genetic and environmental factors. Evidence of genetic involvement includes: associations with HLA-DR3, HLA-DR2, Fc! receptors (Fc!R) IIA and IIIA, and hereditary complement component deficiencies, as well as familial aggregation, monozygotic twin concordance >20%, "s >10, purported linkage at 1q41–42, and inbredmouse strains that consistently develop lupus. We have completed a genome scan in 94 extended multiplex pedigrees by using model-based linkage analysis. Potential [log10 of the odds for linkage (lod) > 2.0] SLE loci have been identified at chromosomes 1q41, 1q23, and 11q14–23 in African-Americans; 14q11, 4p15, 11q25, 2q32, 19q13, 6q26–27, and 12p12–11 in European- Americans; and 1q23, 13q32, 20q13, and 1q31 in all pedigrees combined. An effect for the Fc!RIIA candidate polymorphism) at 1q23 (lod # 3.37 in African-Americans) is syntenic with linkage in a murine model of lupus. Sib-pair and multipoint nonparametric analyses also support linkage (P < 0.05) at nine loci detected by using two-point lod score analysis (lod > 2.0). Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects. Originally published Proceedings of the National Academy of Sciences, Vol. 95, No. 25, Dec 1998
    URI
    http://hdl.handle.net/10342/3360
    Subject
     Systemic lupus erythematosus; SLE loci; Racial origin 
    Date
    1998-12
    Citation:
    APA:
    Moser, Kathy L., & Neas, Barbara R., & Salmon, Jane E., & Yu, Hua, & Gray-McGuire, Courtney, & Asundi, Neeraj, & Bruner, Gail R., & Fox, Jerome, & Kelly, Jennifer, & Henshall, Stephanie, & Bacino, Debra, & Dietz, Myron, & Hogue, Robert, & Koelsch, Gerald, & Nightingale, Lydia, & Shaver, Tim, & Abdou, Nabih I., & Albert, Daniel A., & Carson, Craig, & Petri, Michelle, & Treadwell, Edward L., & James, Judith A., & Harley, John B.. (December 1998). Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees. Proceedings of the National Academy of Sciences, 95(25), 14869- 14874. Retrieved from http://hdl.handle.net/10342/3360

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    MLA:
    Moser, Kathy L., and Neas, Barbara R., and Salmon, Jane E., and Yu, Hua, and Gray-McGuire, Courtney, and Asundi, Neeraj, and Bruner, Gail R., and Fox, Jerome, and Kelly, Jennifer, and Henshall, Stephanie, and Bacino, Debra, and Dietz, Myron, and Hogue, Robert, and Koelsch, Gerald, and Nightingale, Lydia, and Shaver, Tim, and Abdou, Nabih I., and Albert, Daniel A., and Carson, Craig, and Petri, Michelle, and Treadwell, Edward L., and James, Judith A., and Harley, John B.. "Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees". Proceedings of the National Academy of Sciences. 95:25. (14869-14874), December 1998. May 29, 2023. http://hdl.handle.net/10342/3360.
    Chicago:
    Moser, Kathy L. and Neas, Barbara R. and Salmon, Jane E. and Yu, Hua and Gray-McGuire, Courtney and Asundi, Neeraj and Bruner, Gail R. and Fox, Jerome and Kelly, Jennifer and Henshall, Stephanie and Bacino, Debra and Dietz, Myron and Hogue, Robert and Koelsch, Gerald and Nightingale, Lydia and Shaver, Tim and Abdou, Nabih I. and Albert, Daniel A. and Carson, Craig and Petri, Michelle and Treadwell, Edward L. and James, Judith A. and Harley, John B., "Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees," Proceedings of the National Academy of Sciences 95, no. 25 (December 1998), http://hdl.handle.net/10342/3360 (accessed May 29, 2023).
    AMA:
    Moser, Kathy L., Neas, Barbara R., Salmon, Jane E., Yu, Hua, Gray-McGuire, Courtney, Asundi, Neeraj, Bruner, Gail R., Fox, Jerome, Kelly, Jennifer, Henshall, Stephanie, Bacino, Debra, Dietz, Myron, Hogue, Robert, Koelsch, Gerald, Nightingale, Lydia, Shaver, Tim, Abdou, Nabih I., Albert, Daniel A., Carson, Craig, Petri, Michelle, Treadwell, Edward L., James, Judith A., Harley, John B.. Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees. Proceedings of the National Academy of Sciences. December 1998; 95(25): 14869-14874. http://hdl.handle.net/10342/3360. Accessed May 29, 2023.
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    • Rheumatology
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    East Carolina University

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