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    Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease

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    Author
    Offenbacher, Steven; Beck, James D.; Moss, Kevin; Mendoza, Luisito; Paquette, David W.; Barrow, David A.; Couper, David J.; Steward, Dawn D.; Falkner, Karen L.; Graham, Susan P.; Grossi, Sara; Gunsolley, John C.; Madden, Theresa; Maupome, Gerardo; Trevisan, Maurizio; Van Dyke, Thomas E.; Genco, Robert J.
    Abstract
    Background- In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers. Methods- Subjects were randomized to either community care or protocol provided scaling and root planing to evaluate effects on periodontal status and systemic levels of high-sensitivity Creactive protein (hs-CRP). Results- After 6 months, there was a significant reduction in mean probing depth and extent of 4- or 5-mm pockets. However, there were no significant differences in attachment levels, bleeding upon probing, or extent of subgingival calculus comparing subjects assigned to protocol therapy (n = 151) to those assigned to community care (n = 152). Using intent-to-treat analyses, there was no significant effect on serum hs-CRP levels at 6 months. However, 48% of the subjects randomized to community care received preventive or periodontal treatments. Secondary analyses demonstrated that consideration of any preventive or periodontal care (i.e., any treatment) compared to no treatment showed a significant reduction in the percentage of people with elevated hs-CRP (values >3 mg/l)at 6 months. However, obesity nullified the periodontal treatment effects on hs-CRP reduction. The adjusted odds ratio for hs-CRP levels >3 mg/l at 6 months for any treatment versus no treatment among non-obese individuals was 0.26 (95%confidence interval: 0.09 to 0.72), adjusting for smoking, marital status, and gender. Conclusion- This pilot study demonstrated the critical role of considering obesity as well as rigorous preventive and periodontal care in trials designed to reduce cardiovascular risk. Originally published Journal of Periodontology, Vol. 80, No. 2, Feb 2009
    URI
    http://hdl.handle.net/10342/3368
    Subject
     C-reactive protein; Cardiovascular Diseases; Controlled clinical trials; Obesity; Periodontitis; Prevention 
    Date
    2009-02
    Citation:
    APA:
    Offenbacher, Steven, & Beck, James D., & Moss, Kevin, & Mendoza, Luisito, & Paquette, David W., & Barrow, David A., & Couper, David J., & Steward, Dawn D., & Falkner, Karen L., & Graham, Susan P., & Grossi, Sara, & Gunsolley, John C., & Madden, Theresa, & Maupome, Gerardo, & Trevisan, Maurizio, & Van Dyke, Thomas E., & Genco, Robert J.. (February 2009). Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease. , (. Retrieved from http://hdl.handle.net/10342/3368

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Offenbacher, Steven, and Beck, James D., and Moss, Kevin, and Mendoza, Luisito, and Paquette, David W., and Barrow, David A., and Couper, David J., and Steward, Dawn D., and Falkner, Karen L., and Graham, Susan P., and Grossi, Sara, and Gunsolley, John C., and Madden, Theresa, and Maupome, Gerardo, and Trevisan, Maurizio, and Van Dyke, Thomas E., and Genco, Robert J.. "Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease". . . (.), February 2009. August 11, 2022. http://hdl.handle.net/10342/3368.
    Chicago:
    Offenbacher, Steven and Beck, James D. and Moss, Kevin and Mendoza, Luisito and Paquette, David W. and Barrow, David A. and Couper, David J. and Steward, Dawn D. and Falkner, Karen L. and Graham, Susan P. and Grossi, Sara and Gunsolley, John C. and Madden, Theresa and Maupome, Gerardo and Trevisan, Maurizio and Van Dyke, Thomas E. and Genco, Robert J., "Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease,"  , no. (February 2009), http://hdl.handle.net/10342/3368 (accessed August 11, 2022).
    AMA:
    Offenbacher, Steven, Beck, James D., Moss, Kevin, Mendoza, Luisito, Paquette, David W., Barrow, David A., Couper, David J., Steward, Dawn D., Falkner, Karen L., Graham, Susan P., Grossi, Sara, Gunsolley, John C., Madden, Theresa, Maupome, Gerardo, Trevisan, Maurizio, Van Dyke, Thomas E., Genco, Robert J.. Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease. . February 2009; () . http://hdl.handle.net/10342/3368. Accessed August 11, 2022.
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    East Carolina University

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