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    Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins

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    Author
    Ross, Ted M.; Xu, Yan; Green, Thomas D.; Montefiori, David C.; Robinson, Harriet L.
    Abstract
    DNA vaccination can elicit both humoral and cellular immune responses and can confer protection against several pathogens. However, DNA vaccines expressing the envelope (Env) protein of human immunodeficiency virus (HIV) have been relatively ineffective at generating high titer, long-lasting, neutralizing antibodies in a variety of animal models. In this study, we report that fusion of Env and the complement component, C3d, in a DNA vaccine, enhances the titers of antibody to Env. Plasmids were generated that expressed a secreted form of Env (sgp120) from three isolates of HIV and these same forms fused to three tandem copies of the murine homologue of C3d (sgp120-3C3d). Analyses of titers and avidity maturation of the raised antibody indicated that immunizations with each of the sgp120-3C3d-expressing DNAs accelerated both the onset and the avidity maturation of antibody to Env. Originally published AIDS Research and Human Retroviruses, Vol. 17, No. 9, June 2001
    URI
    http://hdl.handle.net/10342/3389
    Subject
     DNA vaccination; Titers; Avidity maturation 
    Date
    2001-06-10
    Citation:
    APA:
    Ross, Ted M., & Xu, Yan, & Green, Thomas D., & Montefiori, David C., & Robinson, Harriet L.. (June 2001). Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins. AIDS Research and Human Retroviruses, (17:9), p.829-835. Retrieved from http://hdl.handle.net/10342/3389

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Ross, Ted M., and Xu, Yan, and Green, Thomas D., and Montefiori, David C., and Robinson, Harriet L.. "Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins". AIDS Research and Human Retroviruses. 17:9. (829-835.), June 2001. April 19, 2021. http://hdl.handle.net/10342/3389.
    Chicago:
    Ross, Ted M. and Xu, Yan and Green, Thomas D. and Montefiori, David C. and Robinson, Harriet L., "Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins," AIDS Research and Human Retroviruses 17, no. 9 (June 2001), http://hdl.handle.net/10342/3389 (accessed April 19, 2021).
    AMA:
    Ross, Ted M., Xu, Yan, Green, Thomas D., Montefiori, David C., Robinson, Harriet L.. Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins. AIDS Research and Human Retroviruses. June 2001; 17(9) 829-835. http://hdl.handle.net/10342/3389. Accessed April 19, 2021.
    Collections
    • Microbiology and Immunology
    Publisher
    East Carolina University

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