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    The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro

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    Author
    Sayer, A. N.; Hu, Q.; Bourdelais, Andrea J.; Baden, Daniel G.; Gibson, James E.
    Abstract
    Brevetoxins (PbTxs) are highly potent trans-syn polyether neurotoxins produced during blooms of several species of marine dinoflagellates, most notably Karenia brevis. These neurotoxins act on voltage-sensitive sodium channels prolonging the active state. During red tides, the commercial fishing and tourism industries experience millions of dollars of lost revenue. Human consumption of shellfish contaminated with PbTxs results in neurotoxic shellfish poisoning (NSP). Additionally, blooms of K. brevis are potentially responsible for adverse human health effects such as respiratory irritation and airway constriction in coastal residents. There is little information regarding the full range of potential toxic effects caused by PbTxs. Recent evidence suggests that PbTxs are genotoxic substances. The purpose of this study was to determine if PbTxs could induce chromosomal aberrations and inhibit cellular proliferation in CHO-K1-BH4 cells, and if so, could the damage be negated or reduced by the PbTx antagonist brevenal. Results from the chromosomal aberrations assay demonstrated that PbTxs are potent inducers of CHO-K1-BH4 chromosome damage. Results from the inhibition of cellular proliferation assays demonstrated that PbTxs inhibit the ability of CHOK1- BH4 cells to proliferate, an effect which can be reduced with brevenal. Originally published Food and Chemical Toxicology, Vol. 44, No. 7, July 2006
    URI
    http://hdl.handle.net/10342/3395
    Subject
     Brevetoxin; Brevenal; Cell proliferation; Chromosomal aberration; Neurotoxic shellfish poisoning; Genotoxic 
    Date
    2006-07
    Citation:
    APA:
    Sayer, A. N., & Hu, Q., & Bourdelais, Andrea J., & Baden, Daniel G., & Gibson, James E.. (July 2006). The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro. Food and Chemical Toxicology, 44(7), 1082- 1091. Retrieved from http://hdl.handle.net/10342/3395

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Sayer, A. N., and Hu, Q., and Bourdelais, Andrea J., and Baden, Daniel G., and Gibson, James E.. "The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro". Food and Chemical Toxicology. 44:7. (1082-1091), July 2006. December 01, 2023. http://hdl.handle.net/10342/3395.
    Chicago:
    Sayer, A. N. and Hu, Q. and Bourdelais, Andrea J. and Baden, Daniel G. and Gibson, James E., "The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro," Food and Chemical Toxicology 44, no. 7 (July 2006), http://hdl.handle.net/10342/3395 (accessed December 01, 2023).
    AMA:
    Sayer, A. N., Hu, Q., Bourdelais, Andrea J., Baden, Daniel G., Gibson, James E.. The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro. Food and Chemical Toxicology. July 2006; 44(7): 1082-1091. http://hdl.handle.net/10342/3395. Accessed December 01, 2023.
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    • Anatomy and Cell Biology
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    East Carolina University

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