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    A Long Helix from the Central Region of Smooth Muscle Caldesmon

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    Author
    Wang, C.-L. Albert; Chalovich, Joseph M.; Graceffa, Philip; Lu, Renne C.; Mabuchi, Katsuhide; Stafford, Walter F.
    Abstract
    The central region of smooth muscle caldesmon is predicted to form α-helices on the basis of its primary structure. We have isolated a fragment (CT54) that contains this region. The hydrodynamic properties and the electron microscopic images suggest that CT54 is an elongated (35 nm), monomeric molecule. The circular dichroic spectrum yields an overall α-helical content of 55–58%. These results are consistent with the model that the middle portion of CT54 forms a long stretch of single-stranded α-helix. Such a structure, if it in fact exists, is thought to be stabilized by numerous salt bridges between charged residues at positions i and i+4. The structural characteristics of this fragment not only represent an unusual protein configuration but also provide information about the functional role of caldesmon in smooth muscle contraction. Originally published Journal of Biological Chemistry, Vol. 266, No. 21, July 1991
    URI
    http://hdl.handle.net/10342/3413
    Subject
     Smooth muscle; Caldesmon; Helix form 
    Date
    1991-07-25
    Citation:
    APA:
    Wang, C.-L. Albert, & Chalovich, Joseph M., & Graceffa, Philip, & Lu, Renne C., & Mabuchi, Katsuhide, & Stafford, Walter F.. (July 1991). A Long Helix from the Central Region of Smooth Muscle Caldesmon. , (. Retrieved from http://hdl.handle.net/10342/3413

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Wang, C.-L. Albert, and Chalovich, Joseph M., and Graceffa, Philip, and Lu, Renne C., and Mabuchi, Katsuhide, and Stafford, Walter F.. "A Long Helix from the Central Region of Smooth Muscle Caldesmon". . . (.), July 1991. March 02, 2021. http://hdl.handle.net/10342/3413.
    Chicago:
    Wang, C.-L. Albert and Chalovich, Joseph M. and Graceffa, Philip and Lu, Renne C. and Mabuchi, Katsuhide and Stafford, Walter F., "A Long Helix from the Central Region of Smooth Muscle Caldesmon,"  , no. (July 1991), http://hdl.handle.net/10342/3413 (accessed March 02, 2021).
    AMA:
    Wang, C.-L. Albert, Chalovich, Joseph M., Graceffa, Philip, Lu, Renne C., Mabuchi, Katsuhide, Stafford, Walter F.. A Long Helix from the Central Region of Smooth Muscle Caldesmon. . July 1991; () . http://hdl.handle.net/10342/3413. Accessed March 02, 2021.
    Collections
    • Biochemistry and Molecular Biology
    Publisher
    East Carolina University

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