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    Transcriptional Activation of Bordetella Alcaligin Siderophore Genes Requires the AlcR Regulator with Alcaligin as Inducer

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    Author
    Brickman, Timothy J.; Kang, Ho Young; Armstrong, Sandra K.
    Abstract
    Genetic and biochemical studies have established that Fur and iron mediate repression of Bordetella alcaligin siderophore system (alc) genes under iron-replete nutritional growth conditions. In this study, transcriptional analyses using Bordetella chromosomal alc-lacZ operon fusions determined that maximal alc gene transcriptional activity under iron starvation stress conditions is dependent on the presence of alcaligin siderophore. Mutational analysis and genetic complementation confirmed that alcaligin-responsive transcriptional activation of Bordetella alcaligin system genes is dependent on AlcR, a Fur-regulated AraC-like positive transcriptional regulator encoded within the alcaligin gene cluster. AlcR-mediated transcriptional activation is remarkably sensitive to inducer, occurring at extremely low alcaligin concentrations. This positive autogenous control circuit involving alcaligin siderophore as the inducer for AlcR-mediated transcriptional activation of alcaligin siderophore biosynthesis and transport genes coordinates environmental and intracellular signals for maximal expression of these genes under conditions in which the presence of alcaligin in the environment is perceived. Originally published Journal of Bacteriology, Vol. 183, No. 2, Jan 2001
    URI
    http://hdl.handle.net/10342/3459
    Subject
     Bordetella; Alcaligin siderophore; Fur; Iron mediation 
    Date
    2001-01
    Citation:
    APA:
    Brickman, Timothy J., & Kang, Ho Young, & Armstrong, Sandra K.. (January 2001). Transcriptional Activation of Bordetella Alcaligin Siderophore Genes Requires the AlcR Regulator with Alcaligin as Inducer. , (. Retrieved from http://hdl.handle.net/10342/3459

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Brickman, Timothy J., and Kang, Ho Young, and Armstrong, Sandra K.. "Transcriptional Activation of Bordetella Alcaligin Siderophore Genes Requires the AlcR Regulator with Alcaligin as Inducer". . . (.), January 2001. May 19, 2022. http://hdl.handle.net/10342/3459.
    Chicago:
    Brickman, Timothy J. and Kang, Ho Young and Armstrong, Sandra K., "Transcriptional Activation of Bordetella Alcaligin Siderophore Genes Requires the AlcR Regulator with Alcaligin as Inducer,"  , no. (January 2001), http://hdl.handle.net/10342/3459 (accessed May 19, 2022).
    AMA:
    Brickman, Timothy J., Kang, Ho Young, Armstrong, Sandra K.. Transcriptional Activation of Bordetella Alcaligin Siderophore Genes Requires the AlcR Regulator with Alcaligin as Inducer. . January 2001; () . http://hdl.handle.net/10342/3459. Accessed May 19, 2022.
    Collections
    • Microbiology and Immunology
    Publisher
    East Carolina University

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