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Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
(East Carolina University, 2013)
The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ...
TMEFF2 is an epigenetic modulator that promotes androgen independent growth in castration-resistant prostate cancer cells
(East Carolina University, 2014)
While the ability to detect PCa has improved significantly due to PSA screenings, the survival rate for men diagnosed with PCa has remained stagnant, and the disease remains the second leading cause of cancer related deaths ...
Interrelated role of Notch signaling and mTORC pathways in prostate cancer cell survival and growth
(East Carolina University, 2014)
Prostate cancer is currently the second highest leading cause of
cancer death in men. Notch is a transmembrane receptor protein that
is part of a signaling pathway necessary in the normal development of
the prostate. ...
THE EFFECTS OF ACIDIC TUMOR MICROENVIRONMENT ON LYMPHOMA CELL RESPONSES TO CHEMOTHERAPEUTICS
(East Carolina University, 2014)
Acidic tumor microenvironment exists in many types of cancer. Altered glycolytic metabolism of tumor cells and deficient blood supply in tissues are major causes for this phenomenon. Lymphoma cells may have different ...
Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans
(East Carolina University, 2013)
The process of differentiation of stem cells to committed, progenitor specific cell types is well studied but the reverse process of the dedifferentiation of these committed cells back to the undifferentiated state still ...