Clogging information flow in ALS

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Paul and Gitler Science 2014 (format for The ScholarShip).pdf (106.03 KB)

Date

2014-09-05

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Authors

Joseph W. Paul III
Aaron D. Gitler

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Abstract

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurodegenerative disorder that causes a progressive loss of motor neurons, leading to paralysis and death typically within 2 to 5 years of onset. There are no cures and few treatments. ALS shares some genetic and pathological overlap with another neurodegenerative disease, frontotemporal dementia (FTD), which causes changes to personality and language. Mutations in the gene called chromosome 9 open reading frame 72 (C9orf72) are the most common genetic cause of both ALS and FTD. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on [Volume 345 on 5 September 2014], DOI: 10.1126/science.1259461.

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Keywords

Amyotrophic lateral sclerosis , Neurodegeneration , ALS , Frontotemporal dementia , FTD , Nucleolus , Human genetics , Proteotoxicity

Citation

Science; 345:6201 p. 1118-1119

DOI

10.1126/science.1259461

URI

http://hdl.handle.net/10342/4589

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Biology