• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Division of Health Sciences
    • Brody School of Medicine
    • Physiology
    • View Item
    •   ScholarShip Home
    • Division of Health Sciences
    • Brody School of Medicine
    • Physiology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Circadian influences on myocardial infarction

    Thumbnail
    View/ Open
    Clinical Associations for Circadian Rhythms in Myocardial Infarction (384.7Kb)

    Show full item record
    
    Author
    Virag, Jitka A. I.; Lust, Robert M.
    Abstract
    Components of circadian rhythm maintenance, or “clock genes,” are endogenous entrainable oscillations of about 24 h that regulate biological processes and are found in the suprachaismatic nucleus (SCN) and many peripheral tissues, including the heart. They are influenced by external cues, or Zeitgebers, such as light and heat, and can influence such diverse phenomena as cytokine expression immune cells, metabolic activity of cardiac myocytes, and vasodilator regulation by vascular endothelial cells. While it is known that the central master clock in the SCN synchronizes peripheral physiologic rhythms, the mechanisms by which the information is transmitted are complex and may include hormonal, metabolic, and neuronal inputs. Whether circadian patterns are causally related to the observed periodicity of events, or whether they are simply epi-phenomena is not well established, but a few studies suggest that the circadian effects likely are real in their impact on myocardial infarct incidence. Cycle disturbances may be harbingers of predisposition and subsequent response to acute and chronic cardiac injury, and identifying the complex interactions of circadian rhythms and myocardial infarction may provide insights into possible preventative and therapeutic strategies for susceptible populations.
    URI
    http://hdl.handle.net/10342/4724
    Subject
     Circadian rhythms; Clock genes; Circadian patterns; Myocardial Infarction; Acute ischemia; Remodeling; Cardioprotection 
    Date
    2014-10-30
    Citation:
    APA:
    Virag, Jitka A. I., & Lust, Robert M.. (October 2014). Circadian influences on myocardial infarction. Frontiers in Physiology, (5:422), p.1-10. Retrieved from http://hdl.handle.net/10342/4724

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Virag, Jitka A. I., and Lust, Robert M.. "Circadian influences on myocardial infarction". Frontiers in Physiology. 5:422. (1-10.), October 2014. March 03, 2021. http://hdl.handle.net/10342/4724.
    Chicago:
    Virag, Jitka A. I. and Lust, Robert M., "Circadian influences on myocardial infarction," Frontiers in Physiology 5, no. 422 (October 2014), http://hdl.handle.net/10342/4724 (accessed March 03, 2021).
    AMA:
    Virag, Jitka A. I., Lust, Robert M.. Circadian influences on myocardial infarction. Frontiers in Physiology. October 2014; 5(422) 1-10. http://hdl.handle.net/10342/4724. Accessed March 03, 2021.
    Collections
    • 2014-2015 Open Access Publishing Fund
    • Open Access Fund
    • Open Access Publishing Support Fund
    • Physiology

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback