Realistic optical cell modeling and diffraction imaging simulation for study of optical and morphological parameters of nucleus
Author
Zhang, Jun; Feng, Yuanming; Lu, Jun Q.; Sa, Yu; Ding, Junhua; Hu, Xin-Hua; Jiang, Wehnhuan
Abstract
Coherent light scattering presents complex spatial patterns that depend on morphological and molecular features of biological cells. We present a numerical approach to establish realistic optical cell models for generating virtual cells and accurate simulation of diffraction images that are comparable to measured data of prostate cells. With a contourlet transform algorithm, it has been shown that the simulated images and extracted parameters can be used to distinguish virtual cells of different nuclear volumes and refractive indices against the orientation variation. These results demonstrate significance of the new approach for development of rapid cell assay methods through diffraction imaging.
Subject
Date
2016-01
Citation:
APA:
Zhang, Jun, & Feng, Yuanming, & Lu, Jun Q., & Sa, Yu, & Ding, Junhua, & Hu, Xin-Hua, & Jiang, Wehnhuan. (January 2016).
Realistic optical cell modeling and diffraction imaging simulation for study of optical and morphological parameters of nucleus.
Optics Express,
24(1),
366-
377. Retrieved from
http://hdl.handle.net/10342/5155
MLA:
Zhang, Jun, and Feng, Yuanming, and Lu, Jun Q., and Sa, Yu, and Ding, Junhua, and Hu, Xin-Hua, and Jiang, Wehnhuan.
"Realistic optical cell modeling and diffraction imaging simulation for study of optical and morphological parameters of nucleus". Optics Express.
24:1. (366-377),
January 2016.
September 21, 2023.
http://hdl.handle.net/10342/5155.
Chicago:
Zhang, Jun and Feng, Yuanming and Lu, Jun Q. and Sa, Yu and Ding, Junhua and Hu, Xin-Hua and Jiang, Wehnhuan,
"Realistic optical cell modeling and diffraction imaging simulation for study of optical and morphological parameters of nucleus," Optics Express 24, no.
1 (January 2016),
http://hdl.handle.net/10342/5155 (accessed
September 21, 2023).
AMA:
Zhang, Jun, Feng, Yuanming, Lu, Jun Q., Sa, Yu, Ding, Junhua, Hu, Xin-Hua, Jiang, Wehnhuan.
Realistic optical cell modeling and diffraction imaging simulation for study of optical and morphological parameters of nucleus. Optics Express.
January 2016;
24(1):
366-377.
http://hdl.handle.net/10342/5155. Accessed
September 21, 2023.