Browsing Microbiology and Immunology by Author "Bertrand, Fred E."

Now showing items 1-5 of 5

  • Enforced expression of HoxA9 in b-lineage all promotes survival and proliferation of leukemic cells 

    Whelan, Jarrett Thomas (East Carolina University, 2009)
    HoxA9 is frequently overexpressed in acute myeloid leukemia, myelodysplastic syndrome and a subset of acute lymphoblastic leukemia. In mouse models, HoxA9 has been shown to promote leukemogenesis. In spite of a seemingly ...

  • GSK-3 as potential target for therapeutic intervention in cancer 

    McCubrey, James A.; Steelman, Linda S.; Bertrand, Fred E.; Davis, Nicole Marie; Sokolosky, Melissa; Abrams, Stephen L.; Montalto, Giuseppe; D'Assoro, Antonino B.; Libra, Massimo; Nicoletti, Ferdinando; Maestro, Roberta; Basecke, Jorg; Rakus, Dariusz; Gizak, Agnieszka; Demidenko, Zoya N.; Cocco, Lucio; Martelli, Alberto M.; Cervello, Melchiorre (2014-05)
    The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular processes. Aberrant activity of GSK-3 ...

  • Hox-gene expression as a biomarker for igf-1r therapeutics 

    Bertrand, Fred E.; Whelan, Jarrett Thomas (2008-09-25)
    This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or ...

  • Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention 

    McCubrey, James A.; Steelman, L. S.; Bertrand, Fred E.; Davis, Nicole Marie; Abrams, Stephen L.; Montalto, Giuseppe; D'Assoro, Antonino B.; Libra, Massimo; Nicoletti, Ferdinando; Maestro, Roberta; Basecke, Jorg; Cocco, Lucio; Cervello, Melchiorre; Martelli, Alberto M. (2014-01)
    Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated ...

  • Targeting the leukemic stem cell: the Holy Grail of leukemia therapy 

    Misaghian, Negin; Ligresti, Giovanni; Steelman, L. S.; Bertrand, Fred E.; Basecke, Jorg; Libra, Massimo; Nicoletti, Ferdinando; Stivala, F.; Milella, Michele; Tafuri, A.; Cervello, Melchiorre; Martelli, Alberto M.; McCubrey, James A. (East Carolina University, 2009-01)
    Since the discovery of leukemic stem cells (LSCs) over a decade ago, many of their critical biological properties have been elucidated, including their distinct replicative properties, cell surface phenotypes, their ...