Browsing Microbiology and Immunology by Author "Blanchfield, J. Lori"
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Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis
Mannie, Mark D.; Blanchfield, J. Lori; Islam, S.M. Touhidul; Abbott, Derek J. (2012-08)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
Abbott, Derek J.; Blanchfield, J. Lori; Martinson, David A.; Russell, Sean C.; Taslim, Najla; Curtis II, Alan Dale; Mannie, Mark D. (2011)Background Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease ...