Browsing Microbiology and Immunology by Subject "Apoptosis"

Now showing items 1-4 of 4

  • Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium. 

    Sandstrom, Paul A.; Buttke, Thomas M. (East Carolina University, 1993-05-15)
    CCRF-CEM is a human T-cell line originally isolated from a child with acute lymphoblastic leukemia. At cell densities > 2 x 10 cells per ml, CEM cells grow in serum-free medium, but at lower cell densities the cultures ...

  • Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance 

    McCubrey, James A.; Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Wong, Ellis W.T.; Chang, Fumin; Lehmann, Brian D.; Terrian, David M.; Milella, Michele; Tafuri, Agostino; Stivala, Franca; Libra, Massimo; Basecke, Jorg; Evangelisti, Camilla; Martelli, Alberto M.; Franklin, Richard A. (East Carolina University, 2007-08)
    Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ...

  • Synergistic Proapoptotic Activity of Recombinant Trail Plus the AKT Inhibitor Perifosine in Acute Myelogenous Leukemia Cells 

    Tazzari, Pier Luigi; Tabellini, Giovanna; Ricci, Francesca; Papa, Veronica; Bortul, Roberta; Chiarini, Francesca; Evangelisti, Camilla; Martinelli, Giovanni; Bontadini, Andrea; Cocco, Lucio; McCubrey, James A.; Martelli, Alberto M. (East Carolina University, 2008-11-15)
    To potentiate the response of acute myelogenous leukemia (AML) cells to TNF-Related Apoptosis- Inducing Ligand (TRAIL) cytotoxicity, we have examined the efficacy of a combination with perifosine, a novel phosphatidylinositol ...

  • Using death to one's advantage: HIV modulation of apoptosis 

    Ross, TM (East Carolina University, 2001-03)
    Infection by human immunodeficiency virus (HIV) is associated with an early immune dysfunction and progressive destruction of CD4+ T lymphocytes. This progressive disappearance of T cells leads to a lack of immune control ...