• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Division of Health Sciences
    • School of Dental Medicine
    • View Item
    •   ScholarShip Home
    • Division of Health Sciences
    • School of Dental Medicine
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects

    Thumbnail
    View/ Open
    nihms525754.PMC3875298.pdf (669.9Kb)

    Show full item record
    
    Author
    McCarlie, V. Wallace; Hartsfield, James K.; Blum, Janice S.; González-Cabezas, Carlos; Chin, Judith R.; Eckert, George J.; Morford, Lorri A.; Pescovitz, Mark D.; Rodriguez, Henry; Fontana, Margherita; Gregory, Richard L.
    Abstract
    Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II. However, it was not known whether secretory IgA (SIgA) responses to the selected epitopes from HLA-DRB1*04 positive subjects were different compared to controls, or across other caries-related factors such as total IgA (TIgA). Thirty-two total subjects were matched according to HLA type, gender, ethnicity and age. HLA genotyping, oral bacterial, immunoglobulin and antibody analyses were performed. A large observed difference emerged with regard to the natural immune reservoir of TIgA in HLA-DRB1*04 positive subjects, specifically, a 27.6% reduction compared to controls. In contrast to all other epitopes studied, HLA-DRB1*04 positive subjects also exhibited reduced reactivity to I/II epitope 834–853. HLA-DRB1*04 positive subjects exhibited lower specific SIgA activity/TIgA to 834–853 and also a lower specific reactivity to 834–853/whole cell S. mutans UA159. Furthermore, HLA-DRB1*04 positive subjects exhibited lower responses to I/II in its entirety. The large observed difference in TIgA and the 834–853 reactivity pattern across multiple measures suggest potentially important connections pertaining to the link between HLA-DRB1*04 and caries.
    URI
    http://hdl.handle.net/10342/5405
    Subject
     Dental Caries; Streptococcus mutans; I/II; IgA; Immunomodulation; Immunogenetics; HLA-II; DRB1; DRB1*04 
    Date
    2013-11
    Citation:
    APA:
    McCarlie, V. Wallace, & Hartsfield, James K., & Blum, Janice S., & González-Cabezas, Carlos, & Chin, Judith R., & Eckert, George J., & Morford, Lorri A., & Pescovitz, Mark D., & Rodriguez, Henry, & Fontana, Margherita, & Gregory, Richard L.. (November 2013). Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects. Open journal of immunology, (3:3), p.82-92. Retrieved from http://hdl.handle.net/10342/5405

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    McCarlie, V. Wallace, and Hartsfield, James K., and Blum, Janice S., and González-Cabezas, Carlos, and Chin, Judith R., and Eckert, George J., and Morford, Lorri A., and Pescovitz, Mark D., and Rodriguez, Henry, and Fontana, Margherita, and Gregory, Richard L.. "Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects". Open journal of immunology. 3:3. (82-92.), November 2013. August 07, 2022. http://hdl.handle.net/10342/5405.
    Chicago:
    McCarlie, V. Wallace and Hartsfield, James K. and Blum, Janice S. and González-Cabezas, Carlos and Chin, Judith R. and Eckert, George J. and Morford, Lorri A. and Pescovitz, Mark D. and Rodriguez, Henry and Fontana, Margherita and Gregory, Richard L., "Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects," Open journal of immunology 3, no. 3 (November 2013), http://hdl.handle.net/10342/5405 (accessed August 07, 2022).
    AMA:
    McCarlie, V. Wallace, Hartsfield, James K., Blum, Janice S., González-Cabezas, Carlos, Chin, Judith R., Eckert, George J., Morford, Lorri A., Pescovitz, Mark D., Rodriguez, Henry, Fontana, Margherita, Gregory, Richard L.. Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects. Open journal of immunology. November 2013; 3(3) 82-92. http://hdl.handle.net/10342/5405. Accessed August 07, 2022.
    Collections
    • School of Dental Medicine

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback