Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects
Author
McCarlie, V. Wallace; Hartsfield, James K.; Blum, Janice S.; González-Cabezas, Carlos; Chin, Judith R.; Eckert, George J.; Morford, Lorri A.; Pescovitz, Mark D.; Rodriguez, Henry; Fontana, Margherita; Gregory, Richard L.
Abstract
Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II. However, it was not known whether secretory IgA (SIgA) responses to the selected epitopes from HLA-DRB1*04 positive subjects were different compared to controls, or across other caries-related factors such as total IgA (TIgA). Thirty-two total subjects were matched according to HLA type, gender, ethnicity and age. HLA genotyping, oral bacterial, immunoglobulin and antibody analyses were performed. A large observed difference emerged with regard to the natural immune reservoir of TIgA in HLA-DRB1*04 positive subjects, specifically, a 27.6% reduction compared to controls. In contrast to all other epitopes studied, HLA-DRB1*04 positive subjects also exhibited reduced reactivity to I/II epitope 834–853. HLA-DRB1*04 positive subjects exhibited lower specific SIgA activity/TIgA to 834–853 and also a lower specific reactivity to 834–853/whole cell S. mutans UA159. Furthermore, HLA-DRB1*04 positive subjects exhibited lower responses to I/II in its entirety. The large observed difference in TIgA and the 834–853 reactivity pattern across multiple measures suggest potentially important connections pertaining to the link between HLA-DRB1*04 and caries.
Subject
Date
2013-11
Citation:
APA:
McCarlie, V. Wallace, & Hartsfield, James K., & Blum, Janice S., & González-Cabezas, Carlos, & Chin, Judith R., & Eckert, George J., & Morford, Lorri A., & Pescovitz, Mark D., & Rodriguez, Henry, & Fontana, Margherita, & Gregory, Richard L.. (November 2013).
Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects.
Open journal of immunology,
3(3),
82-
92. Retrieved from
http://hdl.handle.net/10342/5405
MLA:
McCarlie, V. Wallace, and Hartsfield, James K., and Blum, Janice S., and González-Cabezas, Carlos, and Chin, Judith R., and Eckert, George J., and Morford, Lorri A., and Pescovitz, Mark D., and Rodriguez, Henry, and Fontana, Margherita, and Gregory, Richard L..
"Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects". Open journal of immunology.
3:3. (82-92),
November 2013.
September 30, 2023.
http://hdl.handle.net/10342/5405.
Chicago:
McCarlie, V. Wallace and Hartsfield, James K. and Blum, Janice S. and González-Cabezas, Carlos and Chin, Judith R. and Eckert, George J. and Morford, Lorri A. and Pescovitz, Mark D. and Rodriguez, Henry and Fontana, Margherita and Gregory, Richard L.,
"Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects," Open journal of immunology 3, no.
3 (November 2013),
http://hdl.handle.net/10342/5405 (accessed
September 30, 2023).
AMA:
McCarlie, V. Wallace, Hartsfield, James K., Blum, Janice S., González-Cabezas, Carlos, Chin, Judith R., Eckert, George J., Morford, Lorri A., Pescovitz, Mark D., Rodriguez, Henry, Fontana, Margherita, Gregory, Richard L..
Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects. Open journal of immunology.
November 2013;
3(3):
82-92.
http://hdl.handle.net/10342/5405. Accessed
September 30, 2023.
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