Browsing Thomas Harriot College of Arts and Sciences by Title
Now showing items 1677-1696 of 3432
-
Investigating candidate genes for an association with skin color pattern in the mimic poison frog Ranitomeya imitator
(East Carolina University, 8/5/2020)Understanding the genetic basis of adaptive traits can help us better understand their evolution. The mimic poison frog, Ranitomeya imitator, is native to Peru. Like many other species of poison frogs, it has aposematic ... -
Investigating Genetic Variants of the Folate One Carbon Metabolism (FOCM) Pathway for Associations with Recurrent Stroke and Measures of Homocysteine
(East Carolina University, 2017-07-17)Stroke is currently the fifth leading cause of death and the leading cause of long-term disability in the United States. Stroke accounts for over 140,000 deaths annually and according to the Centers for Disease Control and ... -
Investigating Intra- and Inter-Molecular Coevolution of Intrinsically Disordered Protein, Prothymosin-alpha
(East Carolina University, 1/13/16)Prothymosin-α (ProTα) is a small, highly acidic protein found in the nuclei of virtually all mammalian tissues. It belongs to a class of proteins known for their lack of a rigid three-dimensional structure called intrinsically ... -
Investigating Novel Chromosome 2 Genetic Variants Associated with Recurrent Stroke
(East Carolina University, 2019-07-18)As the fifth leading cause of death and leading cause of long-term disability, stroke affects 795,000 individuals annually in the United States alone. Recurrent stroke, which is far more deadly and disabling, accounts for ... -
Investigating Scuba Divers' Attitudes To Sustainable Shipwreck Diving In North Carolina
(East Carolina University, 2015)This study examined the ways in which NC scuba divers identify sustainable shipwreck diving activities to gain a better understanding of how their behavior impacts sustainable cultural tourism on the coast of North Carolina. ... -
INVESTIGATING THE EFFECTS OF LARVAL PHENOTYPES ON TRAITS EXHIBITED AT A CRUCIAL LIFE-HISTORY SWITCH POINT
(East Carolina University, 2017-07-25)In organisms with complex life histories, phenotypes exhibited in non-reproductive life stages are often correlated with adult performance and fitness. For example, in anurans (frogs and toads), age and size at metamorphosis ... -
Investigating the genetic interaction between DNA replication proteins Mcm10 and RecQ4 in Drosophila melanogaster
(East Carolina University, 2017-12-12)Necessary to the survival of cellular life is proper replication and maintenance of the genome. Replication proteins Mcm10 and RecQ4 have well-characterized essential roles in assembly, initiation, proper functioning of ... -
Investigating the Impact of Mettl16 Cellular Localization on RNA Binding Preferences
(East Carolina University, 2019-05-14)Recently, mRNA modification by N6-methyladenosine (m6A) has been shown to be involved in post-transcriptional regulation processes including mRNA stability, splicing and promotion of translation. Accordingly, the mRNA ... -
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ... -
Investigating the Microbial Communities Associated with Aluminum Alloys 2024 and 7075
(East Carolina University, 2020-11-17)Aluminum (Al), one of the most versatile, cost-effective, and appealing metals for use in construction, has no known biological function. Al alloys in aquatic environments provide a surface for attachment and can be ... -
INVESTIGATING THE MOLECULAR CONTROL OF ECDYSONE RESPONSE GENE, E74, IN THE DROSOPHILA OVARY.
(East Carolina University, 2017-05-05)Oogenesis is the process by which an egg develops from precursor cells in the ovary. This process has been widely studied; however, many of the molecular mechanisms that regulate oocyte development and growth remain unclear. ... -
INVESTIGATING THE MOLECULAR MECHANISMS UNDERLYING SKIN FRAGILITY IN TP63-LINKED ECTODERMAL DYSPLASIAS
(East Carolina University, 2022-04-28)Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome and ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome are two rare autosomal dominant disorders caused by heterozygous mutations occurring ... -
Investigating the Relationship between Environmental Lead Exposures and the Onset of Alzheimer's Disease Pathologies
(2014)It is been estimated that nearly 5 million Americans suffer from Alzheimer's Disease (AD), making finding its cause one of medicine's top priorities. It has long been known that genetics plays a major role in the development ... -
Investigating the role of CRL5, an ubiquitin ligase, in ovarian follicle development.
(East Carolina University, 2016-07-20)During oogenesis, follicle cells surround maturing oocytes, which produce factors necessary for proper oocyte growth and development. Correct encapsulation of the oocyte by follicle cells is therefore essential for ... -
Investigating the Role of CtBP in Colorectal Cancer
(2015-04-29)Recent studies in breast cancer tissue have demonstrated that C-terminal binding protein (CtBP) over-expression induces stem cell-like features and genome instability; whereas CtBP depletion or caloric restriction reverses ...