Browsing Thomas Harriot College of Arts and Sciences by Title
Now showing items 1688-1707 of 3432
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Investigating the Impact of Mettl16 Cellular Localization on RNA Binding Preferences
(East Carolina University, 2019-05-14)Recently, mRNA modification by N6-methyladenosine (m6A) has been shown to be involved in post-transcriptional regulation processes including mRNA stability, splicing and promotion of translation. Accordingly, the mRNA ... -
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ... -
Investigating the Microbial Communities Associated with Aluminum Alloys 2024 and 7075
(East Carolina University, 2020-11-17)Aluminum (Al), one of the most versatile, cost-effective, and appealing metals for use in construction, has no known biological function. Al alloys in aquatic environments provide a surface for attachment and can be ... -
INVESTIGATING THE MOLECULAR CONTROL OF ECDYSONE RESPONSE GENE, E74, IN THE DROSOPHILA OVARY.
(East Carolina University, 2017-05-05)Oogenesis is the process by which an egg develops from precursor cells in the ovary. This process has been widely studied; however, many of the molecular mechanisms that regulate oocyte development and growth remain unclear. ... -
INVESTIGATING THE MOLECULAR MECHANISMS UNDERLYING SKIN FRAGILITY IN TP63-LINKED ECTODERMAL DYSPLASIAS
(East Carolina University, 2022-04-28)Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome and ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome are two rare autosomal dominant disorders caused by heterozygous mutations occurring ... -
Investigating the Relationship between Environmental Lead Exposures and the Onset of Alzheimer's Disease Pathologies
(2014)It is been estimated that nearly 5 million Americans suffer from Alzheimer's Disease (AD), making finding its cause one of medicine's top priorities. It has long been known that genetics plays a major role in the development ... -
Investigating the role of CRL5, an ubiquitin ligase, in ovarian follicle development.
(East Carolina University, 2016-07-20)During oogenesis, follicle cells surround maturing oocytes, which produce factors necessary for proper oocyte growth and development. Correct encapsulation of the oocyte by follicle cells is therefore essential for ... -
Investigating the Role of CtBP in Colorectal Cancer
(2015-04-29)Recent studies in breast cancer tissue have demonstrated that C-terminal binding protein (CtBP) over-expression induces stem cell-like features and genome instability; whereas CtBP depletion or caloric restriction reverses ... -
Investigating the role of soil legacy effects and community engagement in the management of Lespedeza cuneata, an invasive legume
(East Carolina University, 2020-11-23)Invasive plant species present a growing threat to biodiversity. Many invasive plants are able to recruit microbial symbionts in their novel range and establish plant-soil feedbacks that influence growth and fitness. These ... -
Investigating the role of transcription factor, Trl, during germline development in the Drosophila ovary
(East Carolina University, 2019-07-22)Oogenesis is the process by which an egg develops from undifferentiated cells in the ovary. The Drosophila melanogaster ovary is an assembly line for egg production, making it a great system to investigate initial oocyte ... -
Investigation Into Intermolecular Interactions of Gd3N@C80(OH)n Using Fluorescence Spectroscopy
(2014)The aim of this experiment was to investigate the intermolecular interactions of the endohedral metallofulerene complex in water and various metal cation solutions. These interactions were observed using a methodology ... -
Investigation Into The Scope, Limitations, And Mechanistic Aspects Of A Regioselective Acylation Of Cycloplatinated Complexes
(East Carolina University, 2015)In the reaction of N-isopropyl-N-phenyl-2,2'-bipyridin-6-amine with potassium tetrachloroplatinate, the selective C-H bond activation was complicated by the low selectivity of sp² C-H bond activation in acetonitrile and ... -
Investigation of Molecular Mechanism of Transthyretin Oligomerization Associated with ATTR Amyloidosis
(East Carolina University, 2022-04-27)Transthyretin amyloidosis (ATTR) has classically been diagnosed predominantly post-observation of amyloid fibril deposition on soft tissues within the body, however, recent studies have shown that oligomers which arise ... -
Investigation of possible driving forces on counter-intuitive thermal collapse of intrinsically disordered proteins
(East Carolina University, 2016-08-18)Intrinsically disordered proteins are an emerging class of proteins that contain no secondary or tertiary structure. Through bioinformatics studies it has been predicted that a third of the human proteome consists of ... -
AN INVESTIGATION OF THE TAPHONOMIC EFFECTS OF ANIMAL SCAVENGING
(East Carolina University, 2014)Numerous environmental and human-induced variables that affect decomposition can cloud accurate estimations of the postmortem interval (PMI). For instance, scavenging animals can remove soft tissue and disarticulate and ... -
Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ... -
Investigations into the Oldest Standing Structure in North Carolina
(East Carolina University, 1/13/16)In 2010, Steven and Linda Lane purchased 304 East Queen Street, Edenton, North Carolina. While renovating the structure they discovered that it was much older than previously thought. The results of a dendrochronology ...