Browsing Thomas Harriot College of Arts and Sciences by Author "Danell, Allison Stokes"
-
Benzoate: The Quantitation of Soft Drinks Implicated in Obesity
Marechek, Jennifer (East Carolina University, 2019-04-26)Research has shown that childhood obesity is a leading cause of diseases such as coronary artery disease, hypertension, type 2 diabetes, cancer, osteoarthritis, and many more. With approximately 17 percent of the United ... -
DIFFERENTIATION OF J-SERIES PROSTAGLANDINS AS PRO-APOPTOTIC PRODUCTS OF CANCER CELL METABOLISM
Kobet, Robert A. (East Carolina University, 2016-12-16)Cyclopentenone J-series prostaglandins and prostaglandin-ethanolamide conjugates have been shown to selectively induce endoplasmic reticulum stress-apoptosis in different cancer cell types. These lipids have been identified ... -
IDENTIFICATION OF NOVEL CYTOTOXIC PROSTAGLANDIN METABOLITES PRODUCED IN ARACHIDONOYL ETHANOLAMIDE-TREATED TUMOREGENIC KERATINOCYTES
Thati, Drisheka (East Carolina University, 2012)Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). Our previous data show that AEA is metabolized by COX-2 to pro-apoptotic J-series prostaglandins. COX-2 is an enzyme that ... -
Improving the Reliability of Peptide-Zinc (II) Binding Constant Determination with Mass Spectrometry
Parrish, Whitney (East Carolina University, 2012)Electrospray Ionization Mass Spectrometry (ESI-MS) has become a powerful technique for analyzing protein- and peptide-ligand interactions and quantifying their binding constants (K[subscript]b). However, ESI-MS as an ... -
Insight Into the Location of DNA Xenobiotic Damage by Mass Spectrometry
Mehaffey, Megan R. (2014)Damage to DNA by a bioactivated xenobiotic typically occurs at specific sites within the genome, called hotspots. An example of this is benzo[a]-pyrene (BP), a xenobiotic that enters the body via cigarette smoking. ... -
SYSTEMATIC BENZOATE PRESERVATIVE ANALYSIS IN POPULAR BEVERAGES
Allen, Austin James (East Carolina University, 2019-05-02)Introduction Benzoic acid derivatives (such as sodium benzoate and potassium benzoate) are frequently added to commercial beverages as a preservative. FDA regulations prohibit benzoate levels from exceeding 1000 mg/L (0.1% ... -
Using LC/MS to Quantify Metabolites in Urine Samples Post Clinical Exposure to Benzoates in Beverages
Worthington, Cameron (East Carolina University, 2018-05-01)Evidence has suggested that benzoate consumption has the potential to cause weight loss prevention. Benzoate is conjugated with glycine in the mitochondrial matrix to form hippurate which is eliminated in urine. IRB approval ...