Browsing Thomas Harriot College of Arts and Sciences by Author "McCubrey, James A."
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Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
Davis, Nicole Marie; Sokolosky, Melissa; Stadelman, Kristin; Abrams, Stephen L.; Libra, Massimo; Candido, Saverio; Nicoletti, Ferdinando; Polesel, Jerry; Maestro, Roberta; D'Assoro, Antonino B.; Drobot, Lyudmyla B.; Rakus, Dariusz; Gizak, Agnieszka; Laidler, Piotr; Dulińska-Litewka, Joanna; Basecke, Jorg; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Montalto, Giuseppe; Cervello, Melchiorre; Fitzgerald, Timothy L.; Demidenko, Zoya N.; Martelli, Alberto M.; Cocco, Lucio; Steelman, Linda S.; McCubrey, James A. (2014-7) -
Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line
Long, Jacquelyn M.; Bell, Charles W.; Fagg, W. Samuel IV; Kushman, Mary E.; Becker, Kevin G.; McCubrey, James A.; Farwell, Mary A. (East Carolina University, 2008-10)Bcl-2 is an anti-apoptotic protein that is frequently overex-pressed in cancer cells but its role in carcinogenesis is not clear. We are interested in how Bcl-2 expression affects non-cancerous breast cells and its role ... -
The Role of GSK-3[beta] in MCF-7 Breast Cancer Cell Signaling and Drug Resistance
Sokolosky, Melissa Lynn (East Carolina University, 2011)Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of critical cellular processes. This versatile protein is involved in numerous signaling pathways that influence metabolism, ... -
Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
Davis, Nicole Marie (East Carolina University, 2015)Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ... -
The role of the Bcl-2 protein in the drug resistance of human breast cancer cells
Davis, Julianne M. -
The role of the Bcl-2 protein in the drug resistance of human breast cancer cells
Davis, Julianne M.